Taxonomic group: fungi / Basidiomycota, Basidiomycota, Basidiomycota, Ascomycota
(Phylum: Basidiomycota, Basidiomycota, Basidiomycota, Ascomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
];
infection due to Aspergillus fumigatus [ICD11:
XN5Z7 ]
NCBI PubMed ID: 18676952Publication DOI: 10.1128/EC.00458-07Journal NLM ID: 101130731Publisher: American Society for Microbiology
Correspondence: levery
imbg.ku.dk
Institutions: Department of Chemistry, University of New Hampshire, Durham, USA, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, USA, Department of Pathology and Immunology, Washington University, School of Medicine, St. Louis, USA, Department of Molecular and Cellular Medicine, University of Copenhagen, Copenhagen, Denmark, University of Iowa Carver College of Medicine, Iowa City, USA
The Manα1,3(Xylβ1,2)Manα structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylβ1,2- transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.
biosynthesis, glycosphingolipid, Cryptococcus neoformans, Xylomannan, Xylosyltransferase
Structure type: oligomer ; 1618 [M+2Na]+; 1634 [M+2Na]+
Location inside paper: Fig.3
Compound class: glycolipid
Contained glycoepitopes: IEDB_130701,IEDB_136044,IEDB_137472,IEDB_141794,IEDB_144983,IEDB_152206,IEDB_164174,IEDB_190606,IEDB_983930,SB_165,SB_166,SB_187,SB_195,SB_197,SB_44,SB_67,SB_7,SB_72,SB_88
Methods: ESI-MS, extraction, HPTLC, cell growth, enzymatic assay, evaporation
NCBI Taxonomy refs (TaxIDs): 214684,
40410,
746128
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(later renamed to: Cryptococcus neoformans var. neoformans JEC21)