Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: capsuleAssociated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
];
infection due to Cryptococcus gattii [ICD11:
XN0LE ]
The structure was elucidated in this paperNCBI PubMed ID: 367954Publication DOI: 10.1016/0161-5890(78)90041-XJournal NLM ID: 0010301Publisher: Oxford, Elmsford, NY, Pergamon Press
Institutions: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, USA
The capsular polysaccharide from Cryptococcus neoformans serotype C has been studied using the usual methods for the elucidation of chemical structure. The results are consistent with the occurrence of a polysaccharide having an α-1,3- linked backbone of d-mannopyranoside residues, every other one of which is doubly substituted with two terminal d-xylopyranosyl residues linked β-1,2- and β-1,4- respectively, and with the remainder of the mannosyl residues substituted with a terminal d-glucuronosidopyranosyl residue linked β-1,2-. Alternatively, the terminal glucuronic acid residue may be β-1,2-linked to a mannosyl residue in the chain already hearing a singly branched β-1,4- xylopyranosyl residue, while the neighboring mannosyl residue carries a single branch of β-1.2-xylopyranoside.
hydrolysis, methylation, Mannose, Cryptococcus neoformans, glucuronates
Structure type: suggested polymer biological repeating unit ; 800000
Location inside paper: p.677, structure 2, GXM
Compound class: O-polysaccharide, glucuronoxylomannan
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Methods: methylation, periodate oxidation, gel filtration, GC-MS, acid hydrolysis, GLC, paper chromatography, extraction, optical rotation measurement, acetylation, chromium trioxide oxidation, reduction, CC, cell growth, derivatization, evaporation, sonication, Sevag method, ultracentrifugation
Comments, role: alternative variant of the ID 44402 structure; chemical repeating unit frame was shifted to fit the biological context
Related record ID(s): 44402
NCBI Taxonomy refs (TaxIDs): 37769Reference(s) to other database(s): GTC:G13887QL
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(later renamed to: Cryptococcus gattii VGI C)