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Aspergillus fumigatus

(previously named: Sartorya fumigata, Aspergillus fumigates, Neosartorya fumigata)
(NCBI TaxID 746128, species name lookup)

Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11: XN5Z7

]

NCBI PubMed ID: 18686165
Publication DOI: 10.1080/13693780802258832
Journal NLM ID: 9815835
Publisher: Oxford: Oxford University Press
Correspondence: jplatge

pasteur.fr
Institutions: Institut Pasteur, Aspergillus Unit, Paris, France

Galactofuranose is a major carbohydrate in Aspergillus fumigatus. It became famous in medical mycology as being part of the galactomannan which was shown 30 years ago to be the major antigen circulating in the body fluid of patients suffering from invasive aspergillosis. Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI- anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide.

genetics, cell wall, glycobiology, Aspergillus, aspergillosis

Structure type: structural motif or average structure
Location inside paper: Fig. 3
Compound class: galactomananan
Contained glycoepitopes: IEDB_130701,IEDB_136095,IEDB_136104,IEDB_137472,IEDB_140116,IEDB_141793,IEDB_141795,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_141833,IEDB_143632,IEDB_144983,IEDB_147452,IEDB_147453,IEDB_147454,IEDB_149137,IEDB_152206,IEDB_153220,IEDB_164480,IEDB_190606,IEDB_76933,IEDB_885812,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72

Comments, role: mannose D-configuration and pyranose ring sizes were assumed by CSDB staff

Related record ID(s): 44543, 44544, 44545, 44546, 44547, 44548, 44549, 44550, 44551, 44552, 44553, 44554, 44555
NCBI Taxonomy refs (TaxIDs): 746128
Reference(s) to other database(s): GTC:G30874WP
Show glycosyltransferases

There are 256 chemically distinct structures. Please, select:

*O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@@H]([C@@H](CO)O[C@@H]3O[C@@H]([C@@H](CO)O[C@@H]4O[C@@H]([C@@H](CO)O[C@@H]5O[C@@H]([C@H](O)CO)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)O[C@@H]1O[C@@H]1[C@@H](OC[C@H]2O[C@H](O[C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]3*)[C@@H](O)[C@@H](O)[C@@H]2O)O[C@H](CO[C@@H]2O[C@@H]([C@@H](CO)O[C@@H]3O[C@@H]([C@@H](CO)O[C@@H]4O[C@@H]([C@@H](CO)O[C@@H]5O[C@@H]([C@H](O)CO)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O

SVG MW SMILES 3D mol Ionize

Warning = sub-repeat ending at b?Galf: unknown unit count was assumed to be 3
Warning = sub-repeat ending at b?Galf: unknown unit count was assumed to be 3