Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall,
mother-bud neck
NCBI PubMed ID: 23949603Publication DOI: 10.1038/nrmicro3090Journal NLM ID: 101190261Publisher: London, UK: Nature Publishing Group
Correspondence: Cabib E <enricoc
bdg10.niddk.nih.gov>
Institutions: Laboratory of Biochemistry and Genetics, National institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, USA, the Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ramón y Cajal de Investigaciones Sanitarias, Madrid, Spain
In budding yeast, the neck that connects the mother and daughter cell is the site of essential functions such as organelle trafficking, septum formation and cytokinesis. Therefore, the morphology of this region, which depends on the surrounding cell wall, must be maintained throughout the cell cycle. Growth at the neck is prevented, redundantly, by a septin ring inside the cell membrane and a chitin ring in the cell wall. Here, we describe recent work supporting the hypothesis that attachment of the chitin ring, which forms at the mother–bud neck during budding, to β-1,3-glucan in the cell wall is necessary to stop growth at the neck. Thus, in this scenario, chemistry controls morphogenesis.
Structure type: structural motif or average structure
Location inside paper: abstract
Trivial name: chitin
Compound class: cell wall polysaccharide, glucan
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_153212,IEDB_241099,IEDB_423114,IEDB_423150,SB_74,SB_85
Biological activity: attachment of chitin to glucan in the neck region betwwn the mother and daughter cells blocks further metabolism of the glucan and as a consequence the growth of the cell in that location
Enzymes that release or process the structure: chitin synthase II, chitin synthase III, chitanase, Crh1, Crh2
Comments, role: chitin attached to β-1,3-glucan
Related record ID(s): 41640, 42638, 44855, 44856, 44877, 44889, 44899, 44913, 44915, 44916, 44917, 44923, 44940, 44941
NCBI Taxonomy refs (TaxIDs): 4932Reference(s) to other database(s): GTC:G97099AY
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error