Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
NCBI PubMed ID: 23208465Publication DOI: 10.3390/molecules171214298Journal NLM ID: 100964009Publisher: Basel, Switzerland: MDPI
Correspondence: Túrmina JA <janainaangela
hotmail.com>; Carraro E <emersoncarraro
bol.com.br>; Dos Santos FS <fabio_seidel
hotmail.com>; Silva LA <luizbiologia
hotmail.com>; Alves da Cunha MA <mcunha
utfpr.edu.br>; Dekker RF <rdekker
lakeheadu.ca>; Barbosa AM <anelibarbosa
gmail.com>; Malfatti CRM <crmalfatti
gmail.com>
Institutions: Pharmaceutical Science and Biodiversity Postgraduate Programs, Midwest State University, Campus CEDETEG, Guarapuava, Brazil, Department of Chemistry, Federal Technological University of Parana, Pato Branco, Brazil, Biorefining Research Institute, Lakehead University, Thunder Bay, Canada
Studies evaluating the toxicity caused by fungal exopolysaccharides of the β-(1→6)-D-glucan type are rare. In this study, the toxicological effects of sub-chronic treatments with lasiodiplodan (β-(1→6)-D-glucan from Lasiodiplodia theobromae MMPI) were evaluated in mice through the assessment of biochemical, hematological, and histopathological alterations. Thirty-two mice (16 male, 16 female) were used in this study divided in two groups; one group received lasiodiplodan (50 mg/kg body weight) daily for 28 days via gavage, and another (control group) received saline during the same period. Blood samples were collected via cardiac puncture for hematological and biochemical analyses. Liver, heart, kidney, and spleen were collected for histopathological analysis. Statistical analysis was performed through one-way analysis of variance and only p < 0.05 F-values were presented. Significant reduction in blood glucose in the male group (35%; p < 0.01), transaminases activity in both sexes (AST and ALT; ~35%; p < 0.05), and urea (20%; p < 0.01) in the female group was observed with the lasiodiplodan treatment. The results showed that sub-chronic treatments with lasiodiplodan did not generate hematological and histopathological alterations leading to signs of toxicity in healthy mice, independent of gender.
Lasiodiplodia theobromae MMPI, fungal β-glucan, toxicity evaluation, Swiss albino mice
Structure type: homopolymer
Location inside paper: p.14300, paragraph 1
Trivial name: pustulan, β-1,6-glucan, β-1,6-D-glucan, β(1-6)-D-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-(1,6)-glucan, lasiodiplodan, β-(1,6)-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-1,6-glucan, β-(1,6)-glucan, pustulan, β-(1→6)-glucan PCPS, water-soluble glucan (PS-I)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glycoprotein, glucan, polysaccharide, cell wall glucoprotein
Contained glycoepitopes: IEDB_135614,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_241101,IEDB_983931,SB_192
Methods: biological assays, extraction, cell growth, precipitation
Biological activity: The intake of lasiodiplodan did not produce signs of toxicity in mice, regardless of gender. The administration of lasiodiplodan by gavage induced significant hypoglycaemic activity in male mice (blood glucose reduction of 35%) and a reduction in transaminase activity (ALT and AST) in male and female mice. Sub-chronic treatment with lasiodiplodan did not result in any hematological and histopathological alterations.
Related record ID(s): 45913
NCBI Taxonomy refs (TaxIDs): 45133Reference(s) to other database(s): GTC:G26777BZ, GlycomeDB:
863, CCSD:
50854, CBank-STR:4234
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There is only one chemically distinct structure:
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