Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
The structure was elucidated in this paperNCBI PubMed ID: 24934559Publication DOI: 10.1016/j.mib.2014.05.008Journal NLM ID: 9815056Publisher: London; New York: Current Biology
Correspondence: Fradin C <chantal.fradin
univ-lille2.fr>
Institutions: Université Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, Villeneuve d’Ascq, France, CNRS, UMR 8576, Villeneuve d’Ascq, France, Unité Inserm 995, Lille, France, Université Lille 2, Group Candida and Candidiasis, Faculté de Médecine, Lille, France
Glycosylation is a crucial step in the modification of proteins or sphingolipids that then play a prominent role in fungal biology. Glycosylation controls the structure and plasticity of the fungal cell wall and fungi-host interactions. Non-pathogenic and pathogenic yeasts, such as Saccharomyces cerevisiae and Candida albicans, respectively, have been useful models for analyzing the mannosylation of proteins and sphingolipids, which mainly takes place in the Golgi apparatus. Studies of these yeasts have identified different mannosyltransferases that belong to separate families of glycosyltransferases. The characterization of mannosyltransferases and their activities is essential for deciphering cell wall biogenesis, for identifying mannosides involved in virulence and for designing inhibitors that target specific mannosylation processes.
glycoconjugate, Candida albicans, mannosylation, Saccharomyces cerevisiae
Structure type: oligomer
Location inside paper: fig. 1, lower left structure
Aglycon: (->3) L-Thr/L-Ser (protein)
Compound class: O-glycan
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_983930,SB_136,SB_196,SB_44,SB_67,SB_72
Enzymes that release or process the structure: ScKtr1, ScKtr3, ScMnt1, ScMnn1, ScMnt2, ScMnt3
Related record ID(s): 46356, 46358, 46359, 46360, 46361, 46362, 46363, 46364, 46365, 46366, 46367, 46368, 46369, 46370, 46371, 46372, 46373, 46374, 46375, 46376, 46377, 46378, 46379, 46380, 46381, 46382
NCBI Taxonomy refs (TaxIDs): 4932Reference(s) to other database(s): GTC:G53402KW
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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