Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Enterobacter [ICD11:
XN9W5 
]
NCBI PubMed ID: 21594283Publication DOI: 10.1039/c1cc11574jJournal NLM ID: 9610838Publisher: Cambridge: Royal Society of Chemistry
Correspondence: jon_clardy
hms.harvard.edu
Institutions: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, USA
The study of bacterial symbionts of eukaryotic hosts has become a powerful discovery engine for chemistry. This highlight looks at four case studies that exemplify the range of chemistry and biology involved in these symbioses: a bacterial symbiont of a fungus and a marine invertebrate that produce compounds with significant anticancer activity, and bacterial symbionts of insects and nematodes that produce compounds that regulate multilateral symbioses. In the last ten years, a series of shocking revelations - the molecular equivalents of a reality TV show’s uncovering the true parents of a well known individual or a deeply hidden family secret - altered the study of genetically encoded small molecules, natural products for short. These revelations all involved natural products produced by bacterial symbionts, and while details differed, two main plot lines emerged: parentage, in which the real producers of well known natural products with medical potential were not the organisms from which they were originally discovered, and hidden relationships, in which bacterially produced small molecules turned out to be the unsuspected regulators of complex interactions. For chemists, these studies led to new molecules, new biosynthetic pathways, and an understanding of the biological functions these molecules fulfi11.
bacteria, antibiotics
Structure type: monomer
Location inside paper: Fig. 5, structure 14
Trivial name: byelyankacin
Compound class: glycoside
Contained glycoepitopes: IEDB_136105,IEDB_225177,IEDB_885823
Biological activity: byelyankacin is inhibitor of tyrosinase, a tyrosine specific phenoloxidase
Enzymes that release or process the structure: IsnA, IsnB, GT
Related record ID(s): 47263, 47265, 47266, 47269
NCBI Taxonomy refs (TaxIDs): 554,
1349645
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Pectobacterium carotovorum)