Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
NCBI PubMed ID: 7703963Publication DOI: 10.1248/bpb.17.1460Journal NLM ID: 9311984Publisher: Pharmaceutical Society of Japan
Institutions: Gifu Pharmaceutical University, Gifu, Japan
A water-insoluble, alkali-soluble, glucan (AM-APP), [α]D +160° in 0.4 M NaOH, was isolated from the alkaline extract of the fruiting bodies of Amanita muscaria. The results of chemical and spectroscopic investigations indicate that AM-APP is a linear (1→3)-α-D-glucan with a molecular weigh estimated by gel chromatography of about 42000. Its carboxymethylated product (AM-APP-CM) showed potent antitumor activity against sarcoma 180 in mice, although the native polysaccharide (AM-APP) had little effect. The distribution of carboxymethyl groups in the molecule was analyzed by gas chromatography and mass spectrometry. The degree of substitution of carboxymethyl groups was 0.95 and the substituents were located at O-2, at O-4, at O-6, at O-2 and O-6, and at O-4 and O-6 on glucose
polysaccharide, antitumor activity, (1→3)-α-D-glucan, Amanita muscaria, carboxymethyl group
Structure type: homopolymer ; n=540
Location inside paper: p. 1462, right column, paragraph 1
Trivial name: β-(1,3)-glucan, curdlan
Compound class: glucan, polysaccharide
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_2278476,IEDB_2278477,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: 13C NMR, methylation, GC-MS, acid hydrolysis, GC, GPC, extraction, acetylation, methylation analysis, reduction, dialysis, derivatization, antitumor activity assay
Related record ID(s): 3459, 41552, 41631, 41632, 42138, 42290, 42294, 43554, 47307, 47707, 48305, 48371, 48410, 48411, 48472, 49256, 49257, 49258, 49266, 49279, 49280, 49282, 49290, 50617, 50648, 50654, 50665, 50671, 50861, 102752
NCBI Taxonomy refs (TaxIDs): 511Reference(s) to other database(s): GTC:G51056AN
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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