Taxonomic group: bacteria / Actinobacteria
(Phylum: Actinobacteria)
Associated disease: infection due to Actinomadura [ICD11:
XN8P7 
]
NCBI PubMed ID: 2964225Publication DOI: 10.1128/aac.31.12.1961Journal NLM ID: 0315061Institutions: Merrell-Dow Research Institute, Lepetit Research Center, Gerenzano, Italy
In the course of a search for glycopeptide antibiotics having novel biological properties, we isolated A40926. Produced by an actinomycete of the genus Actinomadura, A40926 is a complex of four main factors which contain a fatty acid as part of a glycolipid attached to the peptide backbone. Its activity was, in most respects, similar to that of other glycopeptides, such as vancomycin and teicoplanin. However, in addition to inhibiting gram-positive bacteria, A40926 was very active against Neisseria gonorrhoeae. A40926 was rapidly bactericidal for N. gonorrhoeae clinical isolates at concentrations equal to or slightly higher than the MIC. In mice, levels in serum were higher and more prolonged than those of an equivalent subcutaneous dose of teicoplanin. These properties suggest that A40926 may have potential in the therapy of gonorrhea
glycopeptide, Actinomadura, antibiotic, Vancomycin, teicoplanin, anti-Neisseria activity
Structure type: oligomer ; 1758
Location inside paper: Fig. 1, factor PA
Trivial name: A40926
Compound class: glycoside
Contained glycoepitopes: IEDB_130701,IEDB_144983,IEDB_152206,IEDB_983930,SB_44,SB_67,SB_72
Methods: 1H NMR, FAB-MS, biological assays, cell growth, antibacterial assay
Biological activity: A40926 was unique in its activity against N. gonorrhoeae. In all other respects, its in vitro antibacterial activity appears, thus far, to be similar to that of teicoplanin and vancomycin. Another novel feature of A40926 was its high levels in serum and long half-life in the mouse compared with teicoplanin and vancomycin
Related record ID(s): 47731, 47733, 47734
NCBI Taxonomy refs (TaxIDs): 93944
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Nonomuraea gerenzanensis ATCC 39727)