Taxonomic group: bacteria / Actinobacteria
(Phylum: Actinobacteria)
Associated disease: infection due to Actinomadura [ICD11:
XN8P7 
]
The structure was elucidated in this paperPublication DOI: 10.1039/p19870002103Journal NLM ID: 7505598Publisher: Chemical Society
Institutions: University Chemical Laboratory, Cambridge, UK, Lepetit Research Center, Gerenzamo, Italy
The structure of the two factors of the novel glycopeptide antibiotic A40926 have been determined using a combination of FAB-MS, GC-MS and 1H NMR studies. A40926 Is a member of the vancomycin family of antibiotics and is structurally related to teicoplanin, A35512B and aridicin
glycopeptide, Actinomadura, antibiotic, Vancomycin, teicoplanin, aridicin
Structure type: oligomer ; 1731 [M+H]+
Location inside paper: Fig. 1, structure 1b
Trivial name: A40926
Compound class: glycoside
Contained glycoepitopes: IEDB_130701,IEDB_144983,IEDB_152206,IEDB_983930,SB_44,SB_67,SB_72
Methods: 1H NMR, methylation, NMR-2D, FAB-MS, GC-MS, acid hydrolysis, GC, paper chromatography
Comments, role: atom enumeration is according to the Fig. 1 and Table 2 in the paper
Related record ID(s): 47728, 47733, 47735
NCBI Taxonomy refs (TaxIDs): 1988
Show glycosyltransferases
NMR conditions: in CD2Cl2 / 50%DMSO-d6 / CF3COOD
[as TSV]
13C NMR data:
missing...
1H NMR data:
Linkage Residue H1 H2 H3 H4 H5 H6 H7 H8 H9 H10 H11 H12 H13 H14 H15 H16 H17 H18 H19 H20 H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
1 aDManp
2,2 Subst2
2 aDGlcpNA
Subst 5.37 4.84 6.09 5.49 4.41 4.08 4.50 2.88 3.32 5.06 6.67 6.96 7.12 7.07 7.03 6.93 7.74 6.7 6.39 5.76 5.04 7.06 6.71 6.71 7.64 7.19 7.39 6.75 6.44 2.45
1H NMR data:
| Linkage | Residue | H1 | H2 | H3 | H4 | H5 | H6 | H7 | H8 | H9 | H10 | H11 | H12 | H13 | H14 | H15 | H16 | H17 | H18 | H19 | H20 | H21 | H22 | H23 | H24 | H25 | H26 | H27 | H28 | H29 | H30 |
|---|
| 1 | aDManp | |
| 2,2 | Subst2 | |
| 2 | aDGlcpNA | |
| | Subst | 5.37 | 4.84 | 6.09 | 5.49 | 4.41 | 4.08 | 4.50 | 2.88 | 3.32 | 5.06 | 6.67 | 6.96 | 7.12 | 7.07 | 7.03 | 6.93 | 7.74 | 6.7 | 6.39 | 5.76 | 5.04 | 7.06 | 6.71 | 6.71 | 7.64 | 7.19 | 7.39 | 6.75 | 6.44 | 2.45 |
|
There is only one chemically distinct structure:
Found 
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