Taxonomic group: fungi / Ascomycota, Basidiomycota, Basidiomycota
(Phylum: Ascomycota, Basidiomycota, Basidiomycota)
NCBI PubMed ID: 25239192Publication DOI: 10.1016/j.ijbiomac.2014.09.008Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: mcunha
utfpr.edu.br
Institutions: Departamento de Química, Universidade Tecnológica Federal do Paraná, Pato Branco, Brazil, Departamento de Química - CCE, Universidade Estadual de Londrina, Londrina, Brazil, Biorefining and Biotechnology Consultancy, Londrina, Brazil, Universidade Estadual do Centro-Oeste (Programa de Pós-Graduac¸ ão em Ciências Farmacêuticas), Campus CEDETEG, Guarapuava, Brazil
D-Glucans have triggered increasing interest in commercial applications in the chemical and pharmaceutical sectors because of their technological properties and biological activities. The glucans are foremost among the polysaccharide groups produced by microorganisms with demonstrated activity in stimulating the immune system, and have potential in treating human disease conditions. Chemical alterations in the structure of D-glucans through derivatization (sulfonylation, carboxymethylation, phosphorylation, acetylation) contributes to their increased solubility that, in turn, can alter their biological activities such as antioxidation and anticoagulation. This review surveys and cites the latest advances on the biological and technological potential of D-glucans following chemical modifications through sulfonylation, carboxymethylation, phosphorylation or acetylation, and discusses the findings of their activities. Several studies suggest that chemically modified D-glucans have potentiated biological activity as anticoagulants, antitumors, antioxidants, and antivirals. This review shows that indepth future studies on chemically modified glucans with amplified biological effects will be relevant in the biotechnological field because of their potential to prevent and treat numerous human disease conditions and their clinical complications
exopolysaccharides, α- and β-Glucans, biomolecules
Structure type: homopolymer
Location inside paper: Table 1
Trivial name: pustulan, β-1,6-glucan, β-1,6-D-glucan, β(1-6)-D-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-(1,6)-glucan, lasiodiplodan, β-(1,6)-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-1,6-glucan, β-(1,6)-glucan, pustulan, β-(1→6)-glucan PCPS, water-soluble glucan (PS-I)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glycoprotein, glucan, polysaccharide, cell wall glucoprotein
Contained glycoepitopes: IEDB_135614,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_241101,IEDB_983931,SB_192
Biological activity: glucan provides anti-proliferative effect on breast cancer MCF-7 cells and has immunostimulatory activity
Related record ID(s): 7724, 8325, 42140, 43301, 43379, 44888, 44927, 44939, 45578, 47842, 47843, 48366, 48412, 48423, 48443, 49291, 101372, 124916, 138263, 143680, 143682, 149870
NCBI Taxonomy refs (TaxIDs): 45133,
5341,
307931Reference(s) to other database(s): GTC:G26777BZ, GlycomeDB:
863, CCSD:
50854, CBank-STR:4234
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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