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Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Organ / tissue: capsule
Associated disease: infection due to Cryptococcus neoformans [ICD11: XN3EH

]

NCBI PubMed ID: 29376918
Publication DOI: 10.3390/jof1030397
Journal NLM ID: 101671827
Publisher: Basel, Switzerland: MDPI AG
Correspondence: Park YD <parky4

mail.nih.gov>; Williamson PR <williamsonpr

mail.nih.gov>
Institutions: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

Pathogens reduce immune recognition of their cell surfaces using a variety of inert structural polysaccharides. For example, capsular polysaccharides play critical roles in microbial survival strategies. Capsules are widely distributed among bacterial species, but relatively rare in eukaryotic microorganisms, where they have evolved considerable complexity in structure and regulation and are exemplified by that of the HIV/AIDS-related fungus Cryptococcus neoformans. Endemic fungi that affect normal hosts such as Histoplasma capsulatum and Blastomyces dermatitidis have also evolved protective polysaccharide coverings in the form of immunologically inert α-(1,3)-glucan polysaccharides to protect their more immunogenic β-(1,3)-glucan-containing cell walls. In this review we provide a comparative update on bacterial and fungal capsular structures and immunogenic properties as well as the polysaccharide masking strategies of endemic fungal pathogens

capsule, Blastomyces, Cryptococcus, Histoplasma, fungal immunity

Structure type: polymer chemical repeating unit
Location inside paper: Fig. 1, F
Compound class: polysaccharide
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_130701,IEDB_131186,IEDB_134624,IEDB_135818,IEDB_136044,IEDB_136906,IEDB_137472,IEDB_140630,IEDB_141794,IEDB_144983,IEDB_144987,IEDB_145668,IEDB_151528,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_190606,IEDB_423153,IEDB_983930,SB_163,SB_165,SB_166,SB_187,SB_195,SB_197,SB_31,SB_44,SB_67,SB_7,SB_72,SB_88

Related record ID(s): 48436
NCBI Taxonomy refs (TaxIDs): 5207
Reference(s) to other database(s): GTC:G46761AB
Show glycosyltransferases

There are 2 chemically distinct structures. Please, select:

*OC[C@H]1O[C@H](OC[C@H]2O[C@H](OC[C@H]3O[C@H](OC[C@H]4O[C@H](*)[C@H](O)[C@@H](O[C@@H]5O[C@H](CO)[C@H](O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]7O)[C@@H]6O)[C@H](O)[C@H]5O)[C@H]4O)[C@H](OC4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3O)[C@H](O)[C@@H](O[C@@H]3O[C@H](CO)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)[C@@H]5O)[C@@H]4O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@H](O[C@@H]4O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]4O)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize