Taxonomic group: protista / Apicomplexa
(Phylum: Apicomplexa)
Host organism: Homo sapiens
Associated disease: malaria due to Plasmodium falciparum [ICD11:
1F40 
, ICD11:
XN69B ]
Publication DOI: 10.1016/B978-0-12-396481-6.00008-8Publisher: Elsevier, Academic Press
Editors: Weiss LM, Kim K
Institutions: Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA, Department of Tropical Medicine and Parasitology-Infectious Diseases, Keio University School of Medicine, Tokyo, Japan, Centre for Infection and Immunity of Lille, Institut Pasteur de Lille, Université Lille Nord de France, France
As obligate intracellular parasites, the Apicomplexa, including Toxoplasma gondii, must either synthesize or acquire essential nutrients while evading host defenses. The metabolic pathways of Toxoplasma reflect the evolutionary relationship of the Apicomplexa to plants as illustrated by the activities of the relict plastid, the apicoplast, as well as other plant-like pathways, such as amylopectin synthesis. Carbohydrate metabolism is developmentally regulated in T. gondii with specialized enzymes for different life-cycle stages. More recent studies have revealed that lipid metabolism consists of unique and conserved scavenging and biosynthetic capabilities. This chapter highlights the metabolic pathways of T. gondii and illustrates important and unique aspects of carbohydrate, lipid and nucleotide metabolism that may pose potential drug targets.
synthesis, carbohydrates, carbohydrate, immunology, infection, parasites, Parasite, Toxoplasma, Toxoplasma gondii, apicomplexa
Structure type: oligomer
Location inside paper: p.269
Compound class: GPI-anchor
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141793,IEDB_141807,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_143632,IEDB_144983,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_474450,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72
Synthetic data: chemical
Comments, role: review
Related record ID(s): 15635
NCBI Taxonomy refs (TaxIDs): 5833
Show glycosyltransferases
There is only one chemically distinct structure:
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