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Taxonomic group: protista / Evosea (Phylum: Evosea)
Host organism: Homo sapiens
Organ / tissue: cyst wall, Life stage: trophozoite
Associated disease: intestinal infections due to Entamoeba [ICD11: 1A36.0

, ICD11: XN3S1

]; amoebic liver abscess [ICD11: 1A36.10

, ICD11: XN3S1

]; infection due to Entamoeba histolytica [ICD11: XN82F

]

NCBI PubMed ID: 28876851
Publication DOI: 10.1101/glycobiology.3e.043
Publisher: Cold Spring Harbor (NY), Cold Spring Harbor Laboratory Press, 2015-2017
Editors: Varki A, Cummings RD, Esko JD
Correspondence: Richard D. Cummings <rcummin1

bidmc.harvard.edu>; Irma van Die <irma.van.die

gmail.com>
Institutions: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA, Department of Molecular Cell Biology & Immunology, VU University Center, Amsterdam, The Netherlands

Parasitic protozoans and helminths (worms) synthesize glycans with structures often different from those typically found in vertebrates and are typically antigenic. Parasites also express glycan-binding proteins (GBPs) involved in host invasion and parasitism. As part of the disease process, parasite glycans can trigger the host's innate immune system, which can lead to the induction of adaptive immune responses. This chapter discusses the major roles of glycoconjugates in parasitic infections.

Structure type: oligomer
Location inside paper: Fig. 43.6, LPPG
Aglycon: lipid
Trivial name: LPPG
Compound class: lipopeptidophosphoglycan
Contained glycoepitopes: IEDB_115013,IEDB_120354,IEDB_123890,IEDB_130645,IEDB_130701,IEDB_131186,IEDB_134624,IEDB_135818,IEDB_136906,IEDB_137472,IEDB_141793,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144983,IEDB_144987,IEDB_144998,IEDB_145001,IEDB_146664,IEDB_150900,IEDB_151528,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_158538,IEDB_190606,IEDB_2346541,IEDB_742246,IEDB_918313,IEDB_983930,IEDB_983931,SB_163,SB_192,SB_198,SB_31,SB_44,SB_67,SB_7,SB_72,SB_87

Comments, role: review

NCBI Taxonomy refs (TaxIDs): 5759
Show glycosyltransferases

There are 16 chemically distinct structures. Please, select:

N[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]2OP(=O)(O)O)O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O[C@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O[C@H]3O[C@H](COP(=O)(O)OCCN[1*]OC(=O)[C@@H](N)COP(=O)(O)O[C@H]4O[C@H](CO[C@@H]5O[C@H](CO[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@H](O)[C@H](O)[C@H]5O)[C@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H]1O

SVG MW SMILES 3D mol Ionize

R1 = polypeptide
Warning = sub-repeat ending at aDGalp: variable unit count (1-20) was assumed to be 1
Warning = sub-repeat ending at aDGlcp: variable unit count (1-22) was assumed to be 1