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Taxonomic group: protista / Apicomplexa (Phylum: Apicomplexa)
Host organism: Homo sapiens
Associated disease: malaria due to Plasmodium falciparum [ICD11: 1F40

, ICD11: XN69B

]

NCBI PubMed ID: 20378610
Publication DOI: 10.1093/glycob/cwq038
Journal NLM ID: 9104124
Publisher: IRL Press at Oxford University Press
Correspondence: schwarz

staff.uni-marburg.de
Institutions: UMR Université-INRA 0483, Immunologie Parasitaire Vaccinologie et Biothérapies anti-infectieuses, UFR Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France

Apicomplexan protozoa are a phylum of parasites that includes pathogens such as Plasmodium, the causative agent of the most severe form of malaria responsible for almost 1 million deaths per year and Toxoplasma gondii causing toxoplasmosis, a disease leading to cerebral meningitis in immunocompromised individuals or to abortion in farm animals or in women that are infected for the first time during pregnancy. The initial immune reactions developed by the host are similar in response to an infection with Plasmodium and Toxoplasma in the sense that the same cells of the innate immune system are stimulated to produce inflammatory cytokines. The glycosylphosphatidylinositol (GPI) anchor is the major carbohydrate modification in parasite proteins and the GPIs are essential for parasite survival. Two immediate GPI precursors with the structures ethanolamine phosphate-6(Manα1-2)Manα1-2Manα1-6Manα1-4GlcN-PI and ethanolamine phosphate-6Manα1-2Manα1-6Man-α1-4-GlcN-PI are synthesized by P. falciparum. Two main structures are synthesized by T. gondii: ethanolamine phosphate-6Manα1-2Manα1-6(GalNAcβ1-4)Manα1-4GlcN-PI and ethanolamine phosphate-6Manα1-2Manα1-6(Glcα1-4GalNAcβ1-4)Manα1-4GlcN-PI. This review describes the biosynthesis of the apicomplexan GPIs and their role in the activation of the host immune system.

immunology, GPI, Toxoplasma gondii, Plasmodium falciparum, apicomplexa

Structure type: oligomer
Location inside paper: abstract, p.803, Fig. 2A, Pfα
Compound class: GPI-anchor
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141181,IEDB_141793,IEDB_141807,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_143632,IEDB_144983,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_176772,IEDB_474450,IEDB_534865,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72

Comments, role: review; LIP = C18:2 (12%)

NCBI Taxonomy refs (TaxIDs): 5833
Show glycosyltransferases

There are too many chemically distinct structures (20) corresponding to the specified structure with alternative fragments (<..>), so only one was processed further:

lXSte(1-1)[lXPam(1-2)[aDManp(1-2)[xXEtN(1-P-6)]aDManp(1-2)aDManp(1-6)aDManp(1-4)aDGlcpN(1-6)]xLmyoIno(1-P-3),lXC18={?}(1-2)]x?Gro

There is only one chemically distinct structure for the variant above:

[1*]OC(COC(=O)CCCCCCCCCCCCCCCCC)COP(=O)(O)O[C@@H]1[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@H]4O[C@H](COP(=O)(O)OCCN)[C@@H](O)[C@H](O)[C@@H]4O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H](O)[C@H](O)[C@@H]3O)[C@H](O)[C@H]2N)[C@H](O)[C@@H](O)[C@H](O)[C@@H]1OC(=O)CCCCCCCCCCCCCCC

SVG MW SMILES 3D mol Ionize

R1 = lXC18={?}