Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall
The structure was elucidated in this paperNCBI PubMed ID: 29144773Publication DOI: 10.1080/01635581.2018.1380204Journal NLM ID: 7905040Publisher: Philadelphia, Franklin Institute Press
Correspondence: Lacroix M <monique.lacroix
iaf.inrs.ca>
Institutions: INRS-Institut Armand-Frappier, Research Laboratories in Sciences Applied to Food, Institute of Nutraceutical and Functional Foods, INRS, Laval, Québec, Canada, Department of Pharmacobiology, Laboratorio de Microbiología Industrial, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara (UdG), Jalisco, Mexico
This study investigated the cancer chemopreventive, the antiradical, and the antiproliferative properties of polysaccharides extracts from cell wall of Saccharomyces boulardii and Kluyveromyces marxianus. β-glucan, mannan, and chitin were also quantified to identify the most important extract responsible for these biological properties. Soluble and insoluble glucans as well as mannoprotein were extracted from cell wall using single hot-alkaline method. Superoxide anion scavenging (antiradical capacity), NAD(P)H: quinone reductase (QR) (EC 1.6.99.2) induction, and antiproliferative assays were done for the evaluation of biological properties of those extracts. The insoluble glucan from S. boulardii revealed the most relevant biological properties by increasing QR activity and exhibiting the highest growth inhibition against colorectal cancer cells. Moreover, high amount of glucan, high glucan/total sugars ratios, and low chitin/glucan ratios were shown to have an impact on enhancing cancer chemopreventive and antiproliferative properties. To our knowledge, this is the first study that demonstrates QR activity by yeast cell wall components in a dose-dependent manner.
Structure type: structural motif or average structure ; 1921000, 2085000
Location inside paper: p. 89, paragraph 1
Trivial name: chitin
Compound class: cell wall polysaccharide, glucan
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_153212,IEDB_241099,IEDB_423114,IEDB_423150,SB_74,SB_85
Methods: biological assays, HPLC, GPC, statistical analysis, radical scavenging assay, centrifugation
Related record ID(s): 48634, 48636, 48650, 48651, 48652, 48689, 48691, 48694, 48715, 48752, 48757, 48764, 48769, 48785, 48794, 48795, 48801, 48804, 48853, 48859, 48872, 48900, 48901, 48902, 48984, 49501, 49523, 49564, 49568, 50015
NCBI Taxonomy refs (TaxIDs): 4911,
252598Reference(s) to other database(s): GTC:G97099AY
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error