Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
NCBI PubMed ID: 29696023Publication DOI: 10.3389/fimmu.2018.00733Journal NLM ID: 101560960Publisher: Lausanne: Frontiers Research Foundation
Correspondence: Hadebe S <sabelo.hadebe
uct.ac.za>
Institutions: Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa, International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa, Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen, United Kingdom, Division of Medical Microbiology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Aberdeen AFGrica Unit, University of Cape Town, Cape Town, South Africa
Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The etiology of the disease is poorly understood, but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens. Fungal-derived allergens represent a major contributing factor in the initiation, persistence, exacerbation, and severity of allergic asthma. C-type lectin like receptors, such as dectin-1, dectin-2, DC-specific intercellular adhesion molecule 3-grabbing nonintegrin, and mannose receptor, recognize many fungal-derived allergens and other structurally similar allergens derived from house dust mites (HDM). In some cases, the fungal derived allergens have been structurally and functionally identified alongside their respective receptors in both humans and mice. In this review, we discuss recent understanding on how selected fungal and HDM derived allergens as well as their known or unknown receptors shape allergic airway diseases.
fungi, Dectin-1, C-type lectin receptors, allergens, sensitization
Structure type: structural motif or average structure
Location inside paper: p. 3, column 1, paragraph 2
Trivial name: chitin
Compound class: cell wall polysaccharide, glucan
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_153212,IEDB_241099,IEDB_423114,IEDB_423150,SB_74,SB_85
Biological activity: binds with PRR2(TLR-2, dectin-1, TLR-9, NOD receptors, mannose receptors, C-type lectin REgIIIγ); 1–10 μm fragments promote anti-inflammatory IL-10 production in a MR-, NOD-, and TLR9- dependent manner; 40–70 μm fragments promote pro-inflammatory cytokine TNF-α in a dectin-1/TLR-2 manner both in vitro and in vivo; 50–100 μm promotes eosinophilic inflammation and alternatively activated macrophages in vivo; initiates innate allergic responses by recruiting IL-4 positive immune cells such as eosinophils and basophils; activates ILC2s by inducing IL-33, IL-25, and TSLP production by the epithelial cells; induces alternative-activated macrophages (AAMs, M2) and eosinophilia an ILC2-dependent manner; induces CCL2 production by epithelial cells, which in turn activated AAMs and eosinophilia in a CCR2-dependent manner
Related record ID(s): 48634, 48636, 48650, 48651, 48652, 48689, 48691, 48694, 48715, 48752, 48757, 48764, 48769, 48785, 48794, 48795, 48801, 48804, 48828, 48853, 48859, 48900, 48901, 48902, 48984
NCBI Taxonomy refs (TaxIDs): 746128Reference(s) to other database(s): GTC:G97099AY
Show glycosyltransferases
There is only one chemically distinct structure:
report error
Found 1 record.
Displayed record 1
