Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
NCBI PubMed ID: 8820922Publication DOI: 10.1248/bpb.19.114Journal NLM ID: 9311984Publisher: Pharmaceutical Society of Japan
Institutions: Gifu Prefectural Health and Environment Research Center, Gifu, Japan, Pharmaceutical University, Gifu, Japan
Immunomodulating activities of three carboxymethylated derivatives (AG-AL-CMS, AG-AL-CMI, and AM-APP-CM) of linear (1→3)-α-D-glucans from Agrocybe cylindracea and Amanita muscaria were evaluated with murine peritoneal macrophages playing an important role in tumor immunity. The ratio of macrophages in peritoneal exudate cells increased more than 50% after the administration of three carboxymethylated (1→3)-α-D-glucans. These carboxymethylated (1→3)-α-D-glucans exhibited higher potentiating activities for macrophages than carboxymethylated linear (1→3)-β-D-glucan (CMPS) in the potency of reduction of nitro blue tetrazolium, products of nitric oxide and the soluble cytotoxic factor, the amount of glucose consumption, and the activation of acid phosphatase. AG-AL-CMS, AG-AL-CMI, and AM-APP-CM were found to induce the tumor regressing factor in mouse serum, although the ability of the induction of this factor was weaker than that of CMPS. The reticuloendothelial system-potentiating activation of three carboxymethylated α-D-glucans was similar to that of the carboxymethylated β-D-glucan. AG-AL-CMS and AG-AL-CMI, but not AM-APP-CM, were suggested to possess a higher-order structure, resulting from the formation of a fluorescent complex with aniline blue
polysaccharide, immunomodulator, macrophage, carboxymethylation, (1→3)-α-D-glucan, tumor regressing activity
Structure type: homopolymer ; n=540
Location inside paper: abstract
Trivial name: β-(1,3)-glucan, curdlan
Compound class: glucan, polysaccharide
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_2278476,IEDB_2278477,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: biological assays, reduction, determination of NO production, phenol-sulfuric acid assay, antitumor activity assay, centrifugation, aniline blue assay, fluorescence spectrophotometry
Related record ID(s): 41552, 41631, 41632, 47304, 47707, 47852, 48305, 48371, 48410, 48411, 48472, 49256, 49257, 49258, 49266, 49281, 49283, 49290, 50617, 50648, 50654, 50665, 50671, 50861
NCBI Taxonomy refs (TaxIDs): 511Reference(s) to other database(s): GTC:G51056AN
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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