Taxonomic group: fungi /
Organ / tissue: cell wall
NCBI PubMed ID: 31807896Publication DOI: 10.1007/82_2019_184Journal NLM ID: 0110513Publisher: Heidelberg: Springer Verlag
Correspondence: andrew.alspaugh
duke.edu
Institutions: Department of Medicine, Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, USA, Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, USA
Chitin and chitosan are two related polysaccharides that provide important structural stability to fungal cell walls. Often embedded deeply within the cell wall structure, these molecules anchor other components at the cell surface. Chitin-directed organization of the cell wall layers allows the fungal cell to effectively monitor and interact with the external environment. For fungal pathogens, this interaction includes maintaining cellular strategies to avoid excessive detection by the host innate immune system. In turn, mammalian and plant hosts have developed their own strategies to process fungal chitin, resulting in chitin fragments of varying molecular size. The size-dependent differences in the immune activation behaviors of variably sized chitin molecules help to explain how chitin and related chitooligomers can both inhibit and activate host immunity. Moreover, chitin and chitosan have recently been exploited for many biomedical applications, including targeted drug delivery and vaccine development.
Structure type: structural motif or average structure
Location inside paper: Fig. 2
Trivial name: chitosan
Compound class: O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_153212,IEDB_241099,IEDB_423114,IEDB_423150,SB_74,SB_85
Related record ID(s): 41553, 44877, 44886, 46311, 46570, 46683, 48760, 48774, 49133, 49502, 49512, 49524, 49653, 50016, 50301, 50303, 50304, 50306, 50308, 50310, 50311, 50314, 50315, 50317, 50319, 50320
NCBI Taxonomy refs (TaxIDs): 4751Reference(s) to other database(s): GTC:G97099AY
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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