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Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11: XN3EH

]

NCBI PubMed ID: 33388126
Publication DOI: 10.1016/j.ddtec.2020.11.002
Journal NLM ID: 101235076
Publisher: Oxford: Elsevier
Correspondence: Nifantiev NE <nen

ioc.ac.ru>
Institutions: Laboratory of Glycoconjugate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Emerging growth of antimycotic resistance among fungal pathogens stimulates the development of corresponding vaccines and therapeutic monoclonal antibodies for active and passive immunization. The polysaccharide components of the fungal cell wall which are not present in humans and mammalians are regarded as promising targets for development of antifungal immunotherapy. Unfortunately, purified fungal antigens related to cell wall polysaccharides are not easily available from natural sources. Moreover, most of these polysaccharides are extremely heterogenic, comprised of different antigenic factors exhibiting different immunogenic properties. Today, the design of efficient antifungal vaccines requires a reliable alternative for such polymers, challenging the synthesis of complex oligosaccharide structures related to polysaccharide antigens. Special attention should be paid to the selection of the target epitope to ensure the protective properties of the vaccine. This review discusses the potential of fungal cell-wall polysaccharides as the basis for development glycoconjugate vaccines on the basis of synthetic oligosaccharides and summarizing contemporary challenges in this field.

synthesis, vaccine, Candida albicans, Cryptococcus neoformans, fungal oligosaccharides

Structure type: oligomer
Location inside paper: p. 39, Fig. 3, IX
Aglycon: vaccine support
Compound class: polysaccharide, mannan
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72

Biological activity: compound is anti-Cryptococcus vaccine candidate

Related record ID(s): 50735, 50736
NCBI Taxonomy refs (TaxIDs): 178876
Reference(s) to other database(s): GTC:G63112QU
Show glycosyltransferases

There is only one chemically distinct structure:

O=C(O)[C@H]1O[C@@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2O[C@@H]2[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O[C@@H]3[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O[C@@H]4[C@H](O)[C@@H](O)O[C@H](CO)[C@H]4O)O[C@H](CO)[C@H]3O)O[C@H](CO)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

SVG MW SMILES 3D mol Ionize