Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11:
XN5Z7 
]
NCBI PubMed ID: 32072265Publication DOI: 10.1007/82_2020_199Journal NLM ID: 0110513Publisher: Heidelberg: Springer Verlag
Correspondence: francois.lemauff
mail.mcgill.ca
Institutions: Research Institute of the McGill University Health Centre, Montreal, Canada
During infection, many fungal pathogens form biofilms within tissues or on biomedical devices. The growth of fungi within biofilms increases dramatically their resistance to both immune defences and antifungal therapies. In the last twenty years, studies have begun to shed light on many of the steps involved in biofilm synthesis and composition, revealing new antifungal strategies. This chapter will focus on the biofilm exopolysaccharides produced by A. fumigatus and C. albicans, the two main causes of human fungal infections. We will review the current state of our understanding of the structure, biosynthesis, and role of exopolysaccharides in biofilm development and function with a view to identifying future strategies for prophylaxis and treatment of these devastating infections.
exopolysaccharides, biofilms, Candida albicans, Aspergillus fumigatus, fungal pathogens
Structure type: homopolymer
Location inside paper: Fig. 1, α-(1,3)-glucan
Trivial name: D-rhamnan, α-1,3-D-glucan, α-1,3-glucan, (1-3)-α-Glucan, 1-3-α-glucan, α-(1,3)-glucan, α-(1,3)glucan, (1-3)-α-glucan, pseudonigeran, α-(1,3)-glucan, pseudonigeran, water-insoluble α-D-glucan (TM-I)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide, D-glucan
Contained glycoepitopes: IEDB_142488,IEDB_144998,IEDB_146664,IEDB_983931,SB_192
Enzymes that release or process the structure: Uge3, Uge5, Ags1-3
NCBI Taxonomy refs (TaxIDs): 746128Reference(s) to other database(s): GTC:G02177KX, CCSD:
49417, CBank-STR:17683, GenDB:HM245773
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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