Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Streptococcus pneumoniae [ICD11:
XN3PW 
]
NCBI PubMed ID: 32920523Publication DOI: 10.1016/j.cbpa.2020.08.003Journal NLM ID: 9811312Publisher: London: Elsevier
Correspondence: Chen Xi <xiichen
ucdavis.edu>
Institutions: Department of Chemistry, University of California Davis, Davis, CA, USA
With the continuing advancement of carbohydrate chemical synthesis, bacterial glycomes have become increasingly attractive and accessible synthetic targets. Although bacteria also produce carbohydrate-containing secondary metabolites, our review here will cover recent chemical synthetic efforts on bacterial surface glycans. The obtained compounds are excellent candidates for the development of improved structurally defined glycoconjugate vaccines to combat bacterial infections. They are also important probes for investigating glycan–protein interactions. Glycosylation strategies applied for the formation of some challenging glycosidic bonds of various uncommon sugars in a number of recently synthesized bacterial surface glycans are highlighted.
synthesis, carbohydrate, glycosyltransferase, glycoconjugate vaccine, Bacterial glycan
Structure type: oligomer
Location inside paper: p.124, Fig.2a, structure 5
Aglycon: (->1)(CH2)3NH2
Compound class: CPS
Contained glycoepitopes: IEDB_115136,IEDB_140630,IEDB_142488,IEDB_146664,IEDB_149553,IEDB_423153,IEDB_983931,SB_192
Synthetic data: chemical
Comments, role: review; synthetic repeating unit of CPS
NCBI Taxonomy refs (TaxIDs): 1313Reference(s) to other database(s): GTC:G97495OL
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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