Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: mycelium
NCBI PubMed ID: 32014479Publication DOI: 10.1016/j.ijbiomac.2020.01.303Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: Yao W <wbyao
cpu.edu.cn>; Gao X <xdgao
cpu.edu.cn>
Institutions: Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology with increasing incidence world widely. Previous studies have indicated that the α-D-glucan YCP purified from the mycelium of the marine fungus Phoma herbarum YS4108 had certain immunomodulatory activities in animal and cell models. In the study, the therapeutic effect and intestinal regulatory activity of YCP (40 mg/kg, intraperitoneal injection) on UC were investigated in dextran sulfate sodium (DSS)-induced colitis mice. The results showed YCP could improve the general symptoms, reestablish the intestinal immune balance, and repair the mucosal barrier in colitis mice. The administration of YCP also significantly increased butyrate and isovaleric acid levels. In addition, YCP resulted in prominent alterations on specific microbiota including Firmicutes, Bacteroidetes, Proteobacteria, Clostridiales, and Lachnospiraceae which are closely related to immune regulation and mucus repair. Therefore, YCP may be a candidate for curing UC because of its conspicuous effects comparable to 5-aminosalicylic acid (5-ASA).
polysaccharide, gut microbiota, ulcerative colitis, short chain fatty acids
Structure type: homopolymer ; 2400
Location inside paper: reference 16
Trivial name: α-1,4-glucan
Compound class: glucan, polysaccharide
Contained glycoepitopes: IEDB_140629,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_420417,IEDB_420418,IEDB_420421,IEDB_857742,IEDB_983931,SB_192
Methods: PCR, ELISA, biological assays, HPLC, extraction, RNA sequencing, RNA extraction, HPGPC, centrifugation, measurement of cytokines, immunohistochemistry, histological analysis
Biological activity: polysaccharide played a therapeutic role in DSS-induced acute colitis mice which manifested as the improvement of clinical symptoms, reestablishment of intestinal immune homeostasis, remission of mucosal injury
Related record ID(s): 41638, 45428, 47107, 49220, 49221, 49222, 49223, 49224
NCBI Taxonomy refs (TaxIDs): 73001Reference(s) to other database(s): GTC:G05740LL
Show glycosyltransferases
There is only one chemically distinct structure:
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