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Taxonomic group: protista / Euglenozoa (Phylum: Euglenozoa)
Host organism: (mammal)
Organ / tissue: cell surface, Life stage: epimastigote
Associated disease: Chagas disease [ICD11: 1F53

, ICD11: XN56V

]; infection due to Trypanosoma cruzi [ICD11: XN56V

]

Publication DOI: 10.2174/1874421401004010084
Journal NLM ID: 101552240
Publisher: Hilversum: Bentham Science Publishers
Correspondence: eliana.bergter

micro.ufrj.br
Institutions: Departamento de Microbiologia Geral, Instituto de Microbiologia Prof. Paulo de Góes (IMPPG), Centro de Ciências da Saúde (CCS) Universidade Federal do Rio de Janeiro (UFRJ), Bloco I, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil

Neutral monohexosylceramides (CMHs) globosides (globotriasyl ceramides), other glycosphingolipids (GSLs) and more complex structures such as glycoinositol-phospholipids(GIPLs) and glycosyl phosphatidylinositol (GPI) anchors have been described in several members of the trypanosomatid family. These highly bioactive molecules are not only components of biological structures but also participants in host-parasite interactions such as macrophage invasion, antigenic presentation and signal transduction. Glycolipid structures have been studied using mass spectrometry (MS).This review describes a wide range of glycoconjugates with unique and complex structures that are present in several trypanosomatid species. Their structures are described in the context of their biological significance.

mass spectrometry, GIPLs, GPI-anchor proteins, GSLs, Trypanosomatids

Structure type: oligomer
Location inside paper: p. 88
Trivial name: GIPL
Compound class: glycoinositol phospholipid
Contained glycoepitopes: IEDB_130701,IEDB_136095,IEDB_136104,IEDB_137472,IEDB_140116,IEDB_141793,IEDB_141807,IEDB_141829,IEDB_143632,IEDB_144983,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_190606,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72

Comments, role: review

NCBI Taxonomy refs (TaxIDs): 5693
Show glycosyltransferases

There is only one chemically distinct structure:

CCCCCCCCCCCCCCCCCCCCCCCC(=O)O[1*]OP(=O)(O)O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O[C@H]1O[C@H](COP(=O)(O)CCN)[C@@H](O[C@H]2O[C@H](CO[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@@H]4O[C@@H]([C@H](O)CO)[C@H](O)[C@H]4O)[C@@H]3O)[C@@H](O)[C@H](O)[C@@H]2O)[C@H](O)[C@H]1N

SVG MW SMILES 3D mol Ionize

R1 = xXSphn