Cervical cancer is the fourth-ranked cancer in the world and is associated with a large number of deaths annually. Chemotherapy and radiotherapy are known as the common therapeutic approaches in the treatment of cervical cancer, but because of their side effects and toxicity, researchers are trying to discovery alternative therapies. β-glucans, a group of glucose polymers that are derived from the cell wall of fungi, bacteria, and etc. it has been showed that β-glucans have some anti-cancer properties which due to their impacts on adaptive and innate immunity. Along to these impacts, these molecules could be used as drug carriers. In this regard, the application of β-glucans is a promising therapeutic option for the cancer prevention and treatment especially for cervical cancer. Herein, we have summarized the therapeutic potential of β-glucans alone or as adjuvant therapy in the treatment of cervical cancer. Moreover, we highlighted β-glucans as drug carriers for preventive and therapeutic purposes.

bacteria, β-Glucans, fungi, cervical cancer

• Compound ID: 4415
  

  -3)-b-D-Glcp-(1-

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  Structure type: homopolymer
  Trivial name: glucan, β-1,3-glucan, curdlan, curdlan-type polysaccharide 13140, paramylon, curdlan, laminarin, β-glucan, curdlan, β-(1,3)-glucan, β-(1,3)-glucan, curdlan, curdlan, β-1,3-glucan, paramylon, reserve polysaccharide, b-glucan, β-1,3-D-glucan, laminaran, botryosphaeran, laminaran type β-D-glucan, latiglucan I, pachymaran, Curdlan, zymosan A, β-glucan, curdlan, laminarin, zymosan, zymosan, glucan particles, zymosan, β-(1-3)-glucan, β-(1,3)-glucan, β-(1,3)glucan, pachymaran, D-glucan (DPn)540, pachyman, laminaran, curdlan, zymosan, zymosan, β-(1,3)-glucan, zymosan A, zymosan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, pachyman, β-(1,3)-glucan, curdlan, callose, a water-insoluble β-(1→3)-glucan, fermentum β-polysaccharide, water-insoluble glucan, alkali-soluble β-glucan (PeA3), alkali-soluble polysaccharide (PCAP), callose, laminarin
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, lipophosphoglycan, glycoprotein, LPG, glucan, polysaccharide, glycoside, β-glucan, β3-glucan, cell wall glucan
  Reference(s) to other database(s): GTC:G51056AN, GlycomeDB:157, CCSD:50049, CBank-STR:4225, CA-RN: 51052-65-4, GenDB:FJ3380871.1
  
   
  
  Agrobacterium, (algae)
  CSDB ID 50617 (all data & tools)
• Compound ID: 22228
  

  -3)-b-D-Glcp-(1-4)-b-D-Glcp-(1-4)-b-D-Glcp-(1-

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  Structure type: structural motif or average structure
  Trivial name: lichenan
  Compound class: glucan, polysaccharide
  Reference(s) to other database(s): GTC:G44166UO
  
   
  
  Cetraria islandica
  CSDB ID 50619 (all data & tools)
• Compound ID: 18228
  

  b-D-Glcp-(1-6)-+ b-D-Glcp-(1-6)-+ | | -3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-

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  Structure type: polymer chemical repeating unit
  Trivial name: lentinan, lentinan (SPG), lentinan (LNT), lentinan, β-glucan
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide, β-glucan, lentinan
  Reference(s) to other database(s): GTC:G14698DR, CCSD:14833, CBank-STR:15884, CA:37339-90-5, GenDB:MT106078
  
   
  
  Lentinus edodes
  CSDB ID 50618 (all data & tools)
• Compound ID: 16857
  

  b-D-Glcp-(1-6)-+ | -3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-

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  Structure type: polymer chemical repeating unit
  Trivial name: β-D-glucan, β-glucan, schizophyllan, carboxymethylglucan, pleuran, scleroglucan, lentinan, GRN, SPG, sizofiran, shizophyllan, Scleroglucan, lentinan-type beta-glucans (Ths-2), b-(1-3,6)-glucan, HEP3, grifolan LE, schizophyllan, scleroglucan, lentinan, termitan, grifolan, schizophyllan, scleroglucan, schizophyllan, sizofiran, grifolan, scleroglucan, schizophyllan, sonifilan, schizophyllan, grifolan, G. frondosa polysaccharide (GFP), alkali-soluble β-glucan (PeA3), schizophyllan (SPG), β-glucan, schizophyllan, β-glucan, schizophyllan, scleroglucan, pleuran
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide, β-glucan, b-glucan, scleroglucan, D-glucan
  Reference(s) to other database(s): GTC:G66305IS, CCSD:49943, CBank-STR:12679, CA:9050-67-3
  
   
  
  Athelia rolfsii
  CSDB ID 50621 (all data & tools)
• Compound ID: 6650
  

  -4)-b-D-Glcp-(1-

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  Structure type: homopolymer
  Trivial name: cellulose, β-(1,4)-glucan, cellulose, β-(1,4)-glucan
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide
  Reference(s) to other database(s): GTC:G75830OM, GlycomeDB:27885, CCSD:50051, CBank-STR:4229
  
   
  
  (Viridiplantae)
  CSDB ID 50616 (all data & tools)