Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: leaf
Publication DOI: 10.1211/146080899128735009Journal NLM ID: 9807134Publisher: London: Pharmaceutical Press
Institutions: Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610, Wilrijk, Antwerp, Belgium, Faculty of Pharmacy, University of Kinshasa, B.P. 212, Kinshasa XI, Congo
Morinda morindoides (Kongobololo or Nkongabululu) is one of the most popular medicinal plants used in the Democratic Republic of Congo. Ten of its constituent flavonoids were evaluated in the xanthine-xanthine oxidase enzymatic system. The compounds were identified by spectroscopic methods as quercetin (1), quercetin 7,4' dimethylether (2), luteolin 7 glucoside (3), apigenin 7 glucoside (4), quercetin 3 rhamnoside (5), kaempferol 3 rhamnoside (6), quercetin 3 rutinoside (7), kaempferol 3 rutinoside (8), chrysoeriol 7 neohesperidoside (9) and kaempferol 7 rhamnosylsophoroside (10). The aglycones chrysoeriol (11), kaempferol (12), luteolin (13) and apigenin (14), obtained by acid hydrolysis of the corresponding glycosides, were also included. Compound 5 exhibited only scavenging activity, 9 and 11 were devoid of any effect against xanthine oxidase and scavenging activity, and the remaining flavonoids exhibited xanthine oxidase inhibiting and superoxide scavenging activity to varying extent. Study of structure activity relationships demonstrated that the activity was not only dependent on the nature of substituents and the substitution site, but also on the nature of the aglycone. These results partially explain and support the use of Morinda morindoides in the treatment of rheumatism.
flavonoid glycoside, Morinda morindoides, xanthine oxidase inhibition, superoxide anion scavanger
Structure type: monomer
Location inside paper: compound 4, table 2(4), table 1(4), apigenin-7-glucoside
Trivial name: cosmosiin, apigenin 7-O-glucoside, rhoifolin, apigenin 7-glucoside, apigetrin
Compound class: glycoside, flavonoid glycoside, flavonol glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_613414,IEDB_983931,SB_192
Methods: statistical analysis, antioxidant activities
Biological activity: Compound 4 showed inhibion of xanthine oxidase activity with IC50 value of 12.10±1.7 μM and superoxide anion scavenging activity with IC50 value of 4.57±0.7 μM.
Comments, role: flavonoid glycosides used in this study were isolated and identified based on published spectral data, see ref. [Cimanga et al 1995a, 1997]
Related record ID(s): 62552, 62554, 62555, 62556, 62557, 62558, 62559
NCBI Taxonomy refs (TaxIDs): 659048Reference(s) to other database(s): CCSD:
50502, CBank-STR:1305
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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