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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Associated disease: infection due to Campylobacter jejuni [ICD11: XN4Q5

]

NCBI PubMed ID: 12183556
Publication DOI: 10.1128/IAI.70.9.5081-5085.2002
Journal NLM ID: 0246127
Publisher: American Society for Microbiology
Correspondence: Ang

Bacl.azr.nl
Institutions: Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands

The core oligosaccharides of Campylobacter jejuni lipopolysaccharides (LPS) display molecular mimicry with gangliosides. Cross-reactive anti-LPS-antiganglioside antibodies have been implicated to show a crucial role in the pathogenesis of the Guillain-Barré and Miller Fisher syndrome. The specificity of the antiganglioside response is thought to depend on the oligosaccharide structure of the ganglioside mimic. To test this hypothesis and to investigate the potential of LPS from Campylobacter strains from enteritis patients to induce an antiganglioside response, we immunized rabbits with purified LPS from eight Campylobacter jejuni reference strains with biochemically well-defined distinct ganglioside mimics and determined the presence of antiganglioside antibodies. All rabbits produced immunoglobulin G (IgM) and IgG anti-LPS antibodies, and the specificity of the cross-reactive antiganglioside response indeed corresponded with the biochemically defined mimic. Most rabbits also had antibody reactivity against additional gangliosides, and there were slight differences in the fine specificity of the antibody response between rabbits that had been immunized with LPS from the same Campylobacter strain. High anti-LPS and antiganglioside titers persisted over a 10-month period. In conclusion, the structure of the LPS only partly determines the antiganglioside specificity. Other strain-specific as well as host-related factors influence the induction and fine-specificity of the cross-reactive anti-LPS-antiganglioside response.

Lipopolysaccharide, biosynthesis, lipopolysaccharides, LPS, oligosaccharide, core, chemistry, Bacterial, human, molecular, antibodies, Oligosaccharides, animal, Campylobacter, Campylobacter jejuni, Carbohydrate Sequence, core oligosaccharide, etiology, ganglioside, gangliosides, Guillain-Barre syndrome, immunization, Immunoglobulin M, immunology, mimicry, molecular mimicry, Molecular Sequence Data, antibody specificity, Cross Reactions, specificity, Miller Fisher syndrome, rabbit, immunoglobulin G, Rabbits

Structure type: oligomer
Location inside paper: Fig.1
Aglycon: lipid A
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130648,IEDB_130650,IEDB_130679,IEDB_130683,IEDB_136044,IEDB_136794,IEDB_137472,IEDB_137473,IEDB_140088,IEDB_141794,IEDB_142487,IEDB_142488,IEDB_144998,IEDB_146100,IEDB_146664,IEDB_149174,IEDB_150933,IEDB_153778,IEDB_1625329,IEDB_190606,IEDB_2189047,IEDB_983931,SB_116,SB_144,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_192,SB_195,SB_25,SB_37,SB_39,SB_6,SB_68,SB_7,SB_76,SB_84,SB_88

Biological activity: ganglioside GM2-mimic

Related record ID(s): 6216, 6307, 6308, 6309, 6310, 6311
NCBI Taxonomy refs (TaxIDs): 197
Reference(s) to other database(s): GTC:G39698FN
Show glycosyltransferases

There is only one chemically distinct structure:

CC(=O)N[C@H]1[C@H](O[C@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](CO)O[C@@H](O[C@H]4[C@@H](O)[C@H](O)[C@@H]([C@@H](O)CO)O[C@@H]4O[C@H]4[C@H](O)[C@@H]([C@H](CO)OP(=O)(O)OCCN)O[C@H](O[C@@H]5[C@H](O)C[C@](O)(C(=O)O)O[C@@H]5[C@H](O)CO)[C@H]4O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O[C@]2(C(=O)O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O2)O[C@H](CO)[C@H](O)[C@@H]1O

SVG MW SMILES 3D mol Ionize