Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: flower
NCBI PubMed ID: 10212384Publication DOI: 10.1248/cpb.47.340Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: Kyoto Pharmaceutical University, Kyoto, Japan
The methanolic extract from the flowers of Chrysanthemum indicum L., Chrysanthemi Indici Flos, was found to show inhibitory activity against rat lens aldose reductase. By bioassay-guided separation, the active components, such as flavone and flavone glycosides, were isolated from the extract together with three new eudes-mane-type sesquiterpenes, kikkanols A, B, and C. The structures of kikkanols A, B, and C were elucidated on the basis of chemical and physicochemical evidence, which included application of the modified Mosher's method.
flavonoid, aldose reductase inhibitor, kikkanol, Chrysanthemum indicum, medicinal flower, eudesmane-type sesquiterpene
Structure type: monomer
Location inside paper: compound 11, chart 1(11)
Trivial name: glucoluteolin, luteolin 7-glucoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside, flavone glycoside, flavone glucoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_613439,IEDB_983931,SB_192
Methods: inhibition studies, TLC, HPLC, HPTLC
Biological activity: Compound 11 showed inhibitory activity on rat lens aldose reductase with IC50 value of 0.99 μM.
Comments, role: compound was isolated and identified based on ref. [10]
Related record ID(s): 63393, 63394
NCBI Taxonomy refs (TaxIDs): 146995Reference(s) to other database(s): CCSD:
50066, CBank-STR:939
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There is only one chemically distinct structure:
Found 
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(previously named: Dendranthema indicum)