Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: bud
NCBI PubMed ID: 10600274Publication DOI: 10.1006/phrs.1999.0562Journal NLM ID: 8907422Publisher: Amsterdam: Elsevier
Institutions: Department of Immunology, Hellenic Anticancer Institute, Athens, Greece, Laboratory of Pharmacognosy, School of Pharmacy, University of Athens, Athens, Greece, Department of Pharmacology, Medical School, University of Ioannina, Ioannina, Greece, Department of Biology, Medical School, UniЁersity of Ioannina, Ioannina, Greece
Two kaempferol coumaroyl glycosides (i.e. platanoside and tiliroside) isolated from the methanolic extract of Platanus orientalis L. buds, were examined for their in vitro cytotoxic activity against a panel of human leukaemic cell lines. Platanoside (1) exhibited cytotoxic activity against most of the cell lines tested, while tiliroside (2) was active against two of the nine tested cell lines. Compound 1, was examined for its effect on the uptake of [(3)H]thymidine as a marker of DNA synthesis. Kaempferol was used as a control.
kaempferol glycosides, Platanus orientalis (Platanaceae), cytotoxic/cytostatic effect
Structure type: monomer
Trivial name: tiliroside, tilirosid
Compound class: glycoside, flavonoid glycoside, flavonol glycoside
Contained glycoepitopes: IEDB_116879,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: radiolabeling, extraction, cytotoxicity assay, MTT
Related record ID(s): 65334
NCBI Taxonomy refs (TaxIDs): 122832
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error