Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: cystic fibrosis (CF) [ICD11:
CA25 
]
The structure was elucidated in this paperPublication DOI: 10.1016/S0141-8130(00)00131-8Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Institutions: Department of Veteran Affairs Medical Center, 500 Foothill Boulevard (151), 84148, Salt Lake City, UT, USA, Departments of Pathology and Biochemistry, Uni6ersity of Utah, Salt Lake City, UT 84148, USA, Consiglio Nazionale delle Ricerche, Istituto per la Chimica e la Tecnologia dei Materiali Polimerici, 6.le A. Doria, 6 -95125 Catania, Italy
The exopolysaccharide produced by a cystic fibrosis clinical isolate of Agrobacterium radiobacter was shown by monosaccharide and methylation analyses, degradation with succinoglycanase and NMR analysis to be a succinoglycan with the structure shown below. (S)-pyruvic acid is found stoichiometrically as 4,6-O-ketal substituent of terminal glucose. Succinic acid is present in 40% of the repeating units and it is attached to O-6 of the 3-linked glucose next to the pyruvate carrying sugar. Some evidence is found that a small amount of succinic acid (ca. 6% of the total) is linked to O-6 of another undetermined glucose. [structure: see text]
polysaccharide, Burkholderia cepacia, cystic fibrosis, Agrobacterium radiobacter, succinoglycan
Structure type: polymer chemical repeating unit
Location inside paper: abstract
Trivial name: succinoglycan
Compound class: EPS
Contained glycoepitopes: IEDB_135614,IEDB_136044,IEDB_137472,IEDB_141794,IEDB_141806,IEDB_142487,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_190606,IEDB_241101,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_6,SB_7,SB_88
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, partial acid hydrolysis, GC-MS, sugar analysis, MS/MS, enzymatic degradation, paper chromatography, HPLC, GPC
Comments, role: NMR chemical shifts were referenced to acetone, although DSS was present.
Related record ID(s): 724, 1005
NCBI Taxonomy refs (TaxIDs): 358
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There is only one chemically distinct structure:
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(later renamed to: Agrobacterium tumefaciens 389)