Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 9466525Journal NLM ID: 0413675Publisher: Oxford: Oxford University Press
Correspondence: scszu
helix.nih.gov
Institutions: National Institutes of Health, Bethesda, Maryland, USA and Carolinas Medical Center, Charlotte, North Carolina, USA.
Escherichia coli O157 causes severe enteritis and the extraintestinal complication hemolytic-uremic syndrome. Serum IgG against the surface polysaccharide antigen, the O-specific polysaccharide of lipopolysaccharide (LPS), may confer protective immunity by lysing the inocula. In a phase 1 clinical study, three investigational vaccines were studied in 87 healthy adults. The vaccines were prepared by covalently binding E. coli O157 O-specific polysaccharide with Pseudomonas aeruginosa recombinant exoprotein A. No significant reactions were reported. Most volunteers (81%) responded with a > 4-fold increase in IgG LPS antibodies 1 week after vaccination; all volunteers responded with a > 4-fold rise at 4 weeks and this level was sustained for 26 weeks after injection. All three vaccines elicited high titers of serum bactericidal activity that roughly correlated with the serum IgG and IgM LPS antibody levels. A phase 2 study in young children is planned.
phase, polysaccharide, Pseudomonas, Pseudomonas aeruginosa, Escherichia, Escherichia coli, Escherichia coli O157, O-specific, O-specific polysaccharide, O157, vaccine, Adult, conjugate, conjugates, recombinant
Structure type: suggested polymer biological repeating unit
Location inside paper: p.385
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130648,IEDB_136045,IEDB_137473,IEDB_1391961,IEDB_141584,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146664,IEDB_152214,IEDB_174333,IEDB_885822,IEDB_983931,SB_192,SB_86
Methods: immunochemical methods
Biological activity: immunochemical data
Comments, role: chemical repeat frame is different in the paper
Related record ID(s): 1619, 8630, 8701, 8988, 20690, 27347, 30269, 30358, 105778, 108677
NCBI Taxonomy refs (TaxIDs): 1045010Reference(s) to other database(s): GTC:G60704LX, GlycomeDB:
27267
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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