Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Pasteurella multocida [ICD11:
XN30D 
]
NCBI PubMed ID: 31678457Publication DOI: 10.1016/j.rvsc.2019.10.011Journal NLM ID: 0401300Publisher: British Veterinary Association
Correspondence: Z. Zhao <zhaozhanqin
126.com>
Institutions: Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China, Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China
Pasteurella multocida possesses a polysaccharide capsule composed of a viscous surface layer that acts as a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. In recent years, a series of important research advances have been made in understanding the biosynthesis and regulatory aspects of the P.multocida capsule. This review systematically examines the serogroups, polysaccharide composition and structures, biosynthetic loci and functions, biosynthesis pathways, and expression regulation mechanisms of the P.multocida capsule, supplying a theoretical basis for the molecular pathogenesis of the P.multocida capsule and the future development of capsular polysaccharide vaccines.
biosynthesis, capsule, glycosaminoglycan, Pasteurella multocida, Expression regulation
Structure type: polymer chemical repeating unit
Location inside paper: p.83, fig.1, Type F, chondroitin
Trivial name: chondroitin
Compound class: CPS
Contained glycoepitopes: IEDB_115136,IEDB_130648,IEDB_137473,IEDB_140630,IEDB_153510,IEDB_423153
Comments, role: review; Type F polymer is an unmodified chondroitin.
Related record ID(s): 762, 1022
NCBI Taxonomy refs (TaxIDs): 747Reference(s) to other database(s): GTC:G43702JT, GlycomeDB:
2738
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error