Salloway S, Mermel LA, Seamans M, Aspinall GO, Nam Shin JE, Kurjanczyk LA, Penner JL Miller-Fisher syndrome associated with Campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside GD3 Infection and Immunity64 (1996)
2945-2949
The structure was elucidated in this paper NCBI PubMed ID:8757818 Journal NLM ID:0246127 Publisher: American Society for Microbiology Institutions: Department of Neurology, Division of Infectious Diseases, Rhode Island Hospital, Providence, Rhode Island 02903, Department of Chemistry, York University, Toronto, Ontario, Canada M3J 1P3, Deparment of Microbiology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
A Campylobacter jejuni strain of serotype O:10 was isolated from a patient who had Miller-Fisher syndrome. In its biochemical reactions and cellular morphology, the isolate was characteristic of typical C. jejuni. Antibodies against extracted lipopolysaccharide (LPS) were detected by passive hemagglutination in the acute- and convalescent-phase patient sera. By sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting with the O:10 antiserum, it was demonstrated that the strain possessed both low- and high-molecular-weight molecules. Chemical analysis of the LPS revealed that the core oligosaccharide has a terminal trisaccharide epitope consisting of two molecules of sialic acid linked to galactose, a structure reflecting the terminal region of human ganglioside GD3. As this trisaccharide is also present in LPS cores of serotype O:19 strains from patients with Guillain-Barre syndrome but not in cores of nonneuropathic C. jejuni, a possible role for the trisaccharide in the etiology of neuropathies is indicated, and a difference for distinguishing neuropathic strains from nonneuropathic strains may be the presence of a sialyltransferase required for the synthesis of this trisaccharide.
Methods: serological methods Biological activity: serological data
Related record ID(s): 8075, 8109 NCBI Taxonomy refs (TaxIDs):197 Reference(s) to other database(s): GTC:G25880KL, GlycomeDB:37758 Show glycosyltransferases
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