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1. (Article ID: 8180)
 
Guo S, Mao W, Yan M, Zhao C, Li N, Shan J, Lin C, Liu X, Guo T, Wang S
Galactomannan with novel structure produced by the coral endophytic fungus Aspergillus ochraceus
Carbohydrate Polymers 105 (2014) 325–333
 

The homogeneous extracellular polysaccharide, AW1, was obtained from the fermented broth of the fungus Aspergillus ochraceus derived from coral Dichotella gemmacea. AW1 was a galactomannan with a molar ratio of mannose and galactose of 2.16:1.00 and a molecular weight of about 29.0kDa. The structure of AW1 was investigated by chemical and spectroscopic methods, including methylation analysis, one- and two-dimensional nuclear magnetic resonance (1D, 2D NMR) and electrospray mass spectrometry with collision-induced dissociation (ES-CID MS/MS) spectroscopic analyses. The results showed that the backbone of AW1 consisted of (1⟶2)-linked α-d-mannopyranose residues. The mannopyranose residues in the backbone were substituted at C-6 by the (1⟶)-linked α-d-mannopyranose units and (1⟶5)-linked β-D-galactofuranose oligosaccharides with different degrees of polymerization. The investigation demonstrated that AW1 was a novel galactomannan with different structural characteristics from other fungal galactomannans, and could be a potential resource of the (1⟶5)-linked β-D-galactofuranose oligosaccharides.

NMR, extracellular polysaccharide, Aspergillus ochraceus, ES-CID MS/MS, galacto-oligosaccharide

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2. (Article ID: 8791)
 
Wang YN, Mou YH, Dong Y, Wu Y, Liu BY, Bai J, Yan DJ, Zhang L, Feng DQ, Pei YH, Hu YC
Diphenyl Ethers from a Marine-Derived Aspergillus sydowii
Marine Drugs 16(11) (2018) 451 (1-11)
 

Six new diphenyl ethers (1–6) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 1–3 was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds 1, 5, 6, and 8–11 were found to exhibit selective cytotoxicity against different cancer cell lines.

structure elucidation, cytotoxicity, Aspergillus sydowii, diphenyl ethers, fungal natural product

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