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1. (Article ID: 8276)
 
Bartmańska A, Huszcza E, Tronina T
Transformation of isoxanthohumol by fungi
Journal of Molecular Catalysis B: Enzymatic 61(3-4) (2009) 221-224
 

Isoxanthohumol is the most abundant and an important prenylated flavonoid present in hopped beers. In order to select microorganisms capable of transforming isoxanthohumol screening tests on 44 fungi cultures were performed. This kind of activity has not been previously examined. Beauveria bassiana AM278 and Absidia glauca AM177 converted isoxanthohumol into glucoside derivatives, whereas Fusarium equiseti AM15 transformed it into (2R)-2″-(2″′-hydroxyisopropyl)-dihydrofurano[2″,3″:7,8]-4′-hydroxy-5-methoxyflavanone with high efficiency. Isoxanthohumol 7-O-β-D-4″′-methoxyglucopyranoside is a new compound.

biotransformation, Beauveria bassiana, Fusarium equiseti, isoxanthohumol, Absidia glauca

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2. (Article ID: 8631)
 
Sordon S, Popłoński J, Huszcza E
Microbial glycosylation of flavonoids
Polish Journal of Microbiology 65(2) (2016) 137-151
 

Flavonoids constitute a large group of polyphenolic compounds naturally found in plants, which have a wide range of biological activity. Although flavonoids are beneficial to human health, their application is limited by their low bioavailability and poor water-solubility. Therefore, recently there has been a particular interest in glycosylated forms of flavonoids, which usually are better soluble, more stable, and more functional compared to their aglycones. Microbial transformation of natural flavonoids may be an attractive way of receiving their glycosylated derivatives in amounts sufficient for the research on the effect of glycoside group on compound properties and for further application of these compounds as ingredients of dietary supplements and pharmaceuticals.

glycosides, biotransformation, microbial glycosylation, flavonoids

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