Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 10799803Publication DOI: 10.1111/j.1574-695X.2000.tb01467.xJournal NLM ID: 9315554Publisher: Elsevier
Correspondence: bcbpc
mahendra.iacs.res.in
Institutions: Department of Biological Chemistry, Indian Association for the Cultivation of Sciences, Calcutta, India
The immunodominant part in the O-antigenic polysaccharide from Escherichia coli O128 was immunologically characterized by an enzyme‐linked immunosorbent assay (ELISA). The antibody specificity was determined by the inhibitory effects of the methyl glycosides of constituent mono‐ and oligosaccharides synthesized related to the O-antigenic polysaccharide from E. coli O128. It was found that methyl α-L-fucopyranoside was the most effective inhibitor amongst the monosaccharides while the highest antibody specificity was directed towards the trisaccharide with the structure: β-D-GalpNAc-(1→6)-[α-L-Fuc-(1→2)-β-D-Galp-1→OMe suggesting that the monospecific antibody has the extended combining site.
Lipopolysaccharide, O-antigenic polysaccharide, Escherichia coli O128, immunodominant, monospecific IgG
Structure type: suggested polymer biological repeating unit
Location inside paper: fig.1
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130648,IEDB_134627,IEDB_136044,IEDB_136045,IEDB_136906,IEDB_137472,IEDB_137473,IEDB_141794,IEDB_142489,IEDB_144562,IEDB_144990,IEDB_147450,IEDB_150767,IEDB_150948,IEDB_151528,IEDB_152214,IEDB_153553,IEDB_167071,IEDB_174333,IEDB_190606,IEDB_241096,IEDB_461711,IEDB_461719,SB_154,SB_165,SB_166,SB_187,SB_195,SB_23,SB_24,SB_25,SB_7,SB_8,SB_86,SB_88
Methods: immunochemical methods
Biological activity: serological data
Comments, role: immunodominant epitope on the OPS; chemical repeat frame is different in the paper; biological repeat frame was based on [PMID:14550554]
Related record ID(s): 4646, 7240, 20681, 22685, 22801
NCBI Taxonomy refs (TaxIDs): 1450177Reference(s) to other database(s): GTC:G12611FV, GlycomeDB:
26360
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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