Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Streptococcus pneumoniae [ICD11:
XN3PW 
]
The structure was elucidated in this paperNCBI PubMed ID: 9692931Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
Correspondence: pererik.jansson
kfcmail.hs.sll.se
Institutions: Clinical Research Centre, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden
The structures of the capsular polysaccharides from Streptococcus pneumoniae types 32F and 32A have been determined by means of NMR spectroscopy as the principal method. It is concluded that both polysaccharides are composed of tetrasaccharide repeating units with a phosphorylcholine (PCho) group linked to the 3-position of the 4-substituted β-L-rhamnose (Rha) residue. Both polysaccharides are substituted with one O-acetyl group at the 2-position of the same β-L-rhamnose residue. In addition, the type-32A polysaccharide is substituted with another O-acetyl group at the 4-position of the 2,3-disubstituted α-D-glucose residue, i.e. the branch-point residue. An unusual detail in the structure is that the side chain is composed of a rhamnosyl phosphate. [chemical structure: see text] In the type-32F polysaccharide R=H, and in the type-32A polysaccharide R=Ac. The structure of C-polysaccharide found in our preparations of type-32F and type-32A capsular polysaccharides is in agreement with that published previously for the pneumococcal common antigen C-polysaccharide [Fischer, W., Behr, T., Hartmann, R., Peter-Katalinic, J. & Egge, H. (1993) Eur. J. Biochem. 215, 851-857; Kulakowska, M., Brisson, J.-R., Griffith, D. W., Young, N. M. & Jennings, H. J. (1993) Can. J. Chem. 71, 644-648].
structure, capsular, polysaccharide, Streptococcus, Streptococcus pneumoniae, capsular polysaccharides, capsular polysaccharide, type, chemical, chemical structure, polysaccharides, phosphorylcholine, Pneumococcus, chemical structures
Structure type: polymer chemical repeating unit
Location inside paper: Abstract
Compound class: CPS
Contained glycoepitopes: IEDB_115009,IEDB_116046,IEDB_136105,IEDB_140624,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_153543,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: NMR
Related record ID(s): 918
NCBI Taxonomy refs (TaxIDs): 1313
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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