Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Campylobacter jejuni [ICD11:
XN4Q5 
]
NCBI PubMed ID: 8982115Journal NLM ID: 8109498Publisher: Elsevier
Correspondence: yuki
dokkyomed.ac.jp
Institutions: Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
N-Acetylgalactosaminyl GD1a (GalNAc-GD1a) is a proposed target molecule for serum antibody in some patients with Guillain-Barre syndrome (GBS) (Kusunoki et al., 1994). We examined autoantibody to GalNAc-GD1a in sera from 58 GBS patients. Eight GBS patients had high IgG anti-GalNAc-GD1a antibody titers, 3 of whom also had high IgM anti-GalNAc-GD1a antibody titers. These 8 patients had experienced gastrointestinal infection before the onset of their neurological symptoms. Campylobacter jejuni was isolated from 4 of them. An absorption test indicated the presence of the GalNAc-GD1a epitope in lipopolysaccharides of C. jejuni. Sera that had anti-GalNAc-GD1a antibody reacted with several acidic glycolipids in bovine peripheral nerve, one of which was identified as N-acetylgalactosaminyl GM1b (GalNAc-GM1b). Serum binding to GalNAc-GM1b was decreased by absorption with GalNAc-GD1a. The presence of GalNAc-GM1b as well as GalNAc-GD1a has been reported in human peripheral nerves. We assume that C. jejuni, which bears the [GalNAc β 1-4 (NeuAc α 2-3) Gal β 1-3 GalNAc β 1-] epitope, is the immunogen and that the glycoconjugates with the epitope are target molecules for the autoantibody in peripheral nerves of some GBS patients.
Lipopolysaccharide, autoantibody, Campylobacter jejuni, Guillain-Barre syndrome, Ga1NAc-GD1a, Ga1NAc-GM1b
Structure type: oligomer
Location inside paper: abstract
Aglycon: GD1a
Trivial name: oligosaccharide epitope
Contained glycoepitopes: IEDB_130648,IEDB_134627,IEDB_136044,IEDB_136095,IEDB_136794,IEDB_137472,IEDB_137473,IEDB_141794,IEDB_146100,IEDB_147450,IEDB_149174,IEDB_150933,IEDB_190606,SB_116,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_195,SB_23,SB_24,SB_25,SB_39,SB_68,SB_7,SB_70,SB_8,SB_84,SB_88,SB_97
Methods: ELISA, TLC-immunostaining
Biosynthesis and genetic data: immunological data, serological data
Comments, role: terminal lipopolysaccharide moiety which is common to GalNAc-GDla and GalNAc-GMlb appears to be the epitope for the IgG autoantibody
NCBI Taxonomy refs (TaxIDs): 197Reference(s) to other database(s): GTC:G89973QY
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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