Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 12453217Journal NLM ID: 8712028Publisher: Blackwell Publishing
Correspondence: cwhitfie
uoguelph.ca
Institutions: Department of Microbiology, University of Guelph, Guelph, ON, Canada
The waa locus on the chromosome of Salmonella enterica encodes enzymes involved in the assembly of the core oligosaccharide region of the lipopolysaccharide (LPS) molecule. To date, there are two known core structures in Salmonella, represented by serovars Typhimurium (subspecies I) and Arizonae (subspecies IIIA). The waa locus for serovar Typhimurium has been characterized. Here, the corresponding locus from serovar Arizonae is described, and the molecular basis for the distinctive structures is established. Eleven of the 13 open reading frames (ORFs) are shared by the two loci and encode conserved proteins of known function. Two polymorphic regions distinguish the waa loci. One involves the waaK gene, the product of which adds a terminal α-1,2-linked N-acetylglucosamine residue that cha
Lipopolysaccharide, genetic, LPS, oligosaccharide, structure, core, gene, terminal, molecular, molecule, locus, conserved, core oligosaccharide, lipopolysaccharide core, lipopolysaccharide core oligosaccharide, protein, Salmonella, assembly, region, Open Reading Frames, Salmonella enterica, enzyme, function, genus, Enzymes, proteins, N-acetylglucosamine, diversity, subspecies, chromosome, Typhimurium
Structure type: oligomer
Location inside paper: Fig.4, A
Aglycon: inner region of the core
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_136906,IEDB_137340,IEDB_137472,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_2189047,IEDB_983931,SB_192,SB_7
Biosynthesis and genetic data: genetic data
Related record ID(s): 838, 911, 912
NCBI Taxonomy refs (TaxIDs): 562Reference(s) to other database(s): GTC:G40162JI, GlycomeDB:
35048
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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