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Taxonomic group: protista / Euglenozoa (Phylum: Euglenozoa)
Host organism: (mammal)
Organ / tissue: Life stage: trypomastigote
Associated disease: Chagas disease [ICD11: 1F53

, ICD11: XN56V

]; infection due to Trypanosoma cruzi [ICD11: XN56V

]

Publication DOI: 10.1002/anie.201203912
Journal NLM ID: 0370543
Publisher: Weinheim: Wiley-VCH
Correspondence: seeberger

mpikg.mpg.de
Institutions: Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces Am M?hlenberg 1, 14424 Potsdam (Germany), Institute of Chemistry and Biochemistry Free University of Berlin Arnimallee 22, 14195 Berlin (Germany), Department of Chemistry, University of Pittsburgh 219 Parkman Avenue, Pittsburgh, PA 15260, USA

Glycosylphosphatidylinositols (GPIs) are complex glycolipids that are covalently linked to the C-terminus of proteins as a posttranslational modification. They anchor the attached protein to the cell membrane and are essential for normal functioning of eukaryotic cells. GPI-anchored proteins are structurally and functionally diverse. Many GPIs have been structurally characterized but comprehension of their biological functions, beyond the simple physical anchoring, remains largely speculative. Work on functional elucidation at a molecular level is still limited. This Review focuses on the roles of GPI unraveled by using synthetic molecules and summarizes the structural diversity of GPIs, as well as their biological and chemical syntheses.

Oligosaccharides, vaccines, proteins, glycosylphosphatidylinositols, protein modifications

Structure type: oligomer
Location inside paper: p. 11439, scheme 2, table 1, table 2
Compound class: GPI-anchor
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141793,IEDB_141807,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_143632,IEDB_144983,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_474450,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72

Comments, role: review

NCBI Taxonomy refs (TaxIDs): 5693
Show glycosyltransferases

There is only one chemically distinct structure:

[1*]OCC(COP(=O)(O)O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O[C@H]1O[C@H](COP(=O)(O)CCN)[C@@H](O[C@H]2O[C@H](CO[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O[C@H]3O[C@H](COP(=O)(O)OCCN)[C@@H](O)[C@H](O)[C@@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H](O)[C@@H]2O)[C@H](O)[C@H]1N)O[2*]

SVG MW SMILES 3D mol Ionize

R1 = ALK
R2 = LIP