Taxonomic group: protista / Euglenozoa
(Phylum: Euglenozoa)
Host organism: (mammal)
Associated disease: Chagas disease [ICD11:
1F53 
, ICD11:
XN56V ];
infection due to Trypanosoma cruzi [ICD11:
XN56V ]
Publication DOI: 10.4052/tigg.24.231Journal NLM ID: 9425898Correspondence: daniel.varon
mpikg.mpg.de
Institutions: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany
Glycosylphosphatidylinositol (GPI) anchors are commonly found in all eukaryotic cells. However, compared to mammalian cells, protozoan parasites express about one hundred times more GPI glycolipids per cell. GPIs are commonly employed by the parasites to anchor surface antigens on the extracellular membrane, although not protein-linked or free GPIs can also be found. Parasitic GPIs are believed to regulate the immune response of the host by protozoa. However, a detailed structure function relationship of GPIs has not been established due to the difficulties in obtaining sufficient quantities of homogeneous material. This review summarizes the structures of characterized parasitic GPIs and their roles in triggering host immune responses. We focus on the recent progress in the chemical synthesis of GPI anchors and application of synthetic materials for development of vaccines and glycan arrays.
glycosylation, vaccine, diagnostic, Glycosylphosphatidylinositol, trypanosomiasis
Structure type: oligomer
Location inside paper: p. 233, table I, T. cruzi 1G7
Compound class: GPI-anchor
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141793,IEDB_141807,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_143632,IEDB_144983,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_474450,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 5693
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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