Found 2 structures.
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1. Compound ID: 10312
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L-gro-a-D-manHepp-(1-7)-L-gro-a-D-manHepp-(1-7)-+ b-D-Glcp-(1-4)-+ a-Kop-(2-4)-+
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b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)-b-D-GalpNAc-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2--/lipid A/
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a-L-Rhap-(1-2)-+ |
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Structure type: oligomer
Aglycon: lipid A
Compound class: LOS
Contained glycoepitopes: IEDB_130648,IEDB_130650,IEDB_130670,IEDB_134627,IEDB_135607,IEDB_135609,IEDB_136044,IEDB_136105,IEDB_137472,IEDB_137473,IEDB_1391961,IEDB_1391963,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141582,IEDB_141584,IEDB_141794,IEDB_142488,IEDB_143260,IEDB_146664,IEDB_153207,IEDB_190606,IEDB_2189047,IEDB_225177,IEDB_226811,IEDB_885822,IEDB_885823,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_23,SB_24,SB_7,SB_8,SB_88
The structure is contained in the following publication(s):
- Article ID: 4274
Bedini E, Cirillo L, Parrilli M "Synthesis of the trisaccharide outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide" -
Carbohydrate Research 349 (2012) 24-32
The synthesis of β-Gal-(1→3)-α-GalNAc-(1→3)-β-GalNAc allyl trisaccharide as the outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide was accomplished through a concise, optimized, multi-step synthesis, having as key steps three glycosylations, that were in-depth studied performing them under several conditions. The target trisaccharide was designed with an allyl aglycone in order to open a future access to the conjugation with an immunogenic protein en route to the development of a synthetic neoglycoconjugate vaccine against this Burkholderia pathogen.
Burkholderia cepacia, trisaccharide, galactose, glycosylation, N-acetyl-galactosamine, orthoester
NCBI PubMed ID: 22209378Publication DOI: 10.1016/j.carres.2011.12.007Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: ebedini@unina.it (E. Bedini)
Institutions: Dipartimento di Chimica Organica e Biochimica, Universita di Napoli 'Federico II', Complesso Universitario Monte S.Angelo, Via Cintia 4, 80126 Napoli, Italy
Methods: 13C NMR, 1H NMR, TLC, MALDI-MS, glycosylation, conjugation, chemical synthesis methods
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2. Compound ID: 10313
Structure type: oligomer
Trivial name: outer core fragment of LOS
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130648,IEDB_134627,IEDB_136044,IEDB_137472,IEDB_137473,IEDB_1391961,IEDB_1391963,IEDB_141582,IEDB_141584,IEDB_141794,IEDB_143260,IEDB_153207,IEDB_190606,IEDB_885822,SB_165,SB_166,SB_187,SB_195,SB_23,SB_24,SB_7,SB_8,SB_88
The structure is contained in the following publication(s):
- Article ID: 4274
Bedini E, Cirillo L, Parrilli M "Synthesis of the trisaccharide outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide" -
Carbohydrate Research 349 (2012) 24-32
The synthesis of β-Gal-(1→3)-α-GalNAc-(1→3)-β-GalNAc allyl trisaccharide as the outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide was accomplished through a concise, optimized, multi-step synthesis, having as key steps three glycosylations, that were in-depth studied performing them under several conditions. The target trisaccharide was designed with an allyl aglycone in order to open a future access to the conjugation with an immunogenic protein en route to the development of a synthetic neoglycoconjugate vaccine against this Burkholderia pathogen.
Burkholderia cepacia, trisaccharide, galactose, glycosylation, N-acetyl-galactosamine, orthoester
NCBI PubMed ID: 22209378Publication DOI: 10.1016/j.carres.2011.12.007Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: ebedini@unina.it (E. Bedini)
Institutions: Dipartimento di Chimica Organica e Biochimica, Universita di Napoli 'Federico II', Complesso Universitario Monte S.Angelo, Via Cintia 4, 80126 Napoli, Italy
Methods: 13C NMR, 1H NMR, TLC, MALDI-MS, glycosylation, conjugation, chemical synthesis methods
- Article ID: 4816
Ziaco M, De Castro C, Silipo A, Corsaro MM, Molinaro A, Iadonisi A, Lanzetta R, Parrilli M, Bedini E "Synthesis of the tetrasaccharide outer core fragment of Burkholderia multivorans lipooligosaccharide" -
Carbohydrate Research 403 (2015) 182-191
The first synthesis of the outer core fragment of Burkholderia multivorans lipooligosaccharide [β-D-Glc-(1→3)-α-D-GalNAc-(1→3)-β-D-GalNAc-(1→3)-l-Rha] as alpha-allyl tetrasaccharide was accomplished. The glycosylations involving GalNAc units were studied in depth testing them under several conditions. This allowed the building of both the α- and the β-configured glycosidic bonds by employing the same GalNAc glycosyl donor, thus considerably shortening the total number of synthetic steps. The target tetrasaccharide was synthesized with an allyl aglycone to allow its future conjugation with an immunogenic protein en route to the development of a synthetic neoglycoconjugate vaccine against the Burkholderia cepacia pathogens.
oligosaccharide, Burkholderia cepacia, glucose, rhamnose, glycosylation, N-acetyl-galactosamine
NCBI PubMed ID: 24933233Publication DOI: 10.1016/j.carres.2014.04.018Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: ebedini@unina.it (E.Bedini)
Institutions: Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S.Angelo, Via Cintia 4, 80126 Napoli, Italy
Methods: 13C NMR, 1H NMR, TLC, chemical synthesis, chemical methods, MALDI-TOF MS, glycosylation, CD
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