Faille C, Wieruszeski JM, Lepage G, Michalski JC, Poulain D, Strecker G 1H NMR spectroscopy of manno-oligosaccharides of the b-1,2-linked series released from the phosphopeptidomannan of Candida albicans vw-32 (serotype A) Biochemical and Biophysical Research Communications181 (1991)
1251-1258
The structure was elucidated in this paper NCBI PubMed ID:1764074 Journal NLM ID:0372516 Publisher: Academic Press Institutions: Unité 42, Institut National de la Santé et de la Recherche Médicale, Villeneuve, d'Ascq, France
Manno-oligosaccharides (DP 2 to greater than 15) were released by mild acid hydrolysis from the phosphopeptidomannan of a Candida albicans strain of A serotype (VW-32). Manno-oligosaccharides ranging from biose to heptaose were obtained in appreciable amount. Structural investigation of these oligosaccharides showed them to be of the β-1,2-linked series. The occurrence of such compounds has already been reported in other strains of Candida albicans. We here report the assignment of the structural reporter groups of each of them, and general rules applicable for the 1H-NMR spectrum analysis of linear manno-oligosaccharide of general structure: Man(β-1--2) [Man(β-1--2)]nMan
Related record ID(s): 105587, 105588, 105589, 105590, 105591, 149846 NCBI Taxonomy refs (TaxIDs):5476 Reference(s) to other database(s): GTC:G19243NZ, CCSD:50506, CBank-STR:17389 Show glycosyltransferases
There are 3 chemically distinct structures. Please, select:
Suzuki S Immunochemical study on mannan, the antigenic polysaccharide of pathogenic yeasts in man of genus Candida Yakugaku Zasshi = Journal of the Pharmaceutical Society of Japan [Japanese]115 (1995)
280-294
NCBI PubMed ID:7541458 Journal NLM ID:0413613 Publisher: Tokyo: Nihon Yakugakkai Institutions: Tohoku College of Pharmacy, Sendai, Japan
This article accounts for the development of immunochemical studies on the antigenic polysaccharide, mannan, a major antigen of pathogenic yeast in man, genus Candida, in order to determine the chemical structures dominating the serological specificities of the parent cells as follows. 1. The serological classification system of 7 medically important Candida species by detecting 10 antigenic factors, 1, 4, 5, 6, 8, 9, 11, 13, 13b, and 34 the corresponding antisera, established by Tsuchiya and his coworkers is documented. 2. The structural studies of Candida mannans until early 1980s, which did not include any evidence for the presence of β-1,2-linked Man unit, the common constituent of antigenic factors, 5, and 6, are also reviewed. 3. The process of structural identification of antigenic factor 5 residing in the mannans of C. albicans, C. tropicalis, and C. stellatoidea, in the phosphate-bound form of β-1,2 linked mannooligosaccharides, is summarized. 4. The results of structural identification of antigenic factors 4 and 6 in the mannans of the acid-stable domains of C. albicans are summarized as follows: In order to isolate oligosaccharides containing β-1,2 and α-1,6 linkages, a modified acetolysis method under mild conditions was established. By means of this procedure, oligosaccharides corresponding to antigenic factors 4 and 6 were successfully isolated, and their structures determined, subsequently. 5. Furthermore, effects of the alteration of cultivation conditions, carbon source, pH and temperature, on the chemical structure of mannans, especially of decrease and/or loss of densities of antigenic factors, 4, 5 and 6, are documented, because of the significance of these findings as basic concepts for in situ assay of Candida cells by antibody-staining technique in patients' foci.
Related record ID(s): 105592, 149841, 149842, 149843, 149844, 149845 NCBI Taxonomy refs (TaxIDs):5476, 5482 Reference(s) to other database(s): GTC:G19243NZ, CCSD:50506, CBank-STR:17389 Show glycosyltransferases
There are 3 chemically distinct structures. Please, select:
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