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1. (Article ID: 10873)
Nishida K, Ohta Y, Araki Y, Ito M, Nagamura Y, Ishiguro I
Inhibitory effects of 'group A saponin' and 'group B saponin' fractions from soybean seed hypocotyls on radical-initiated lipid peroxidation in mouse liver microsomes
Journal of Clinical Biochemistry and Nutrition 15 (1993)
175-184
We examined the inhibitory effects of "group A saponin" and "group B saponin" fractions, which were extracted and separated from soybean seed hypocotyls, on water-soluble 2,2'-azobis(2-amidino-propane) (AAPH)- and lipid-soluble 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN)-initiated lipid peroxidation reactions that were conducted with mouse liver microsomes. The simultaneous addition of the group A saponin fraction dose-dependently inhibited AAPH- or AMVN-initiated lipid peroxidation in microsomes more strongly than that of the group B saponin fraction. The group A saponin fraction inhibited the AAPH-initiated lipid peroxidation with a lag, phase, while it immediately blocked the AMVN-initiated lipid peroxidation. The group A saponin fraction inhibited microsomal AAPH-initiated lipid peroxidation even when added to the reaction mixture after the lag phase period. Microsomes pretreated with the group A saponin fraction showed inhibition of AAPH-initiated lipid peroxidation with a prolonged lag phase, and the saponin fraction-pretreated microsomes showed inhibition of the AMVN-initiated lipid peroxidation in which a lag phase was found. These results indicate that in mouse liver microsomes, the group A saponin fraction from soybean seed hypocotyls, which is present outside and/or near the microsomal membranes, inhibits AAPH-initiated lipid peroxidation by inhibiting the initiation and propagation of this reaction, while it prevents microsomal AMVN-initiated lipid peroxidation mainly by inhibiting the propagation of this reaction. In addition, the present results indicate that the group A saponin fraction can inhibit AAPH- or AMVN-initiated lipid peroxidation in mouse liver microsomes by its presence within the membranes and/or by binding to them.
Antioxidant, lipid peroxidation, soyasaponin, soybean seed hypocotyl, liver microsome (mouse)
Journal NLM ID: 8700907Publisher: Institute Of Applied Biochemistry
Institutions: Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Japan, Department of Internal Medicine, School of Medicine, Fujita Health University, Toyoake, Japan, Department of Clinical Chemistry, School of Health Sciences, Fujita Health University, Toyoake, Japan
Methods: gel filtration, TLC, HPLC, CC, biological assay
The publication contains the following compound(s):
- Compound ID: 23669
|
b-D-Glcp-(1-3)-a-L-Arap-(1-22)-+
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b-D-Glcp-(1-2)-b-D-Galp-(1-2)-b-D-GlcpA-(1-3)-SoyasapogenolA |
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Structure type: oligomer
Trivial name: soyasaponin A1
Compound class: saponin glycoside
Reference(s) to other database(s): CCSD:
48358, CBank-STR:14960
- Compound ID: 23671
|
b-D-Glcp2Ac3Ac4Ac6Ac-(1-3)-a-L-Arap-(1-22)-+
|
b-D-Glcp-(1-2)-b-D-Galp-(1-2)-b-D-GlcpA-(1-3)-SoyasapogenolA |
Show graphically |
Structure type: oligomer
Trivial name: acetyl-soyasaponin A1, acetyl-soyasapogenol A1, acetyl-soyasaponin A1 soyasaponin Ab, acetyl-soyasaponin A1 saponin Ab, soyasaponin Ab
Compound class: saponin glycoside
Reference(s) to other database(s): CCSD:
48357, CBank-STR:14961
- Compound ID: 23676
Structure type: oligomer
Trivial name: soyasaponin II, soyasaponin 2, saponin Bc soyasaponin II, soyasaponin Bc
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
48361, CBank-STR:6049, PubChem:443614
- Compound ID: 23677
Structure type: oligomer
Trivial name: soyasaponin I, astrachrysoside A soyasaponin I, soyasaponin 1, saponin Bb soyasaponin I, soyasaponin Bb
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
48360, CBank-STR:9568, PubChem:122097
- Compound ID: 23678
Structure type: oligomer
Trivial name: soyasaponin III, saponin Bb' soyasaponin III, soyasaponin Bb'
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
48362, CBank-STR:5471
- Compound ID: 23986
Structure type: oligomer
Trivial name: soyasaponin V, acetyl-soyasaponin, saponin Ba soyasaponin V, soyasaponin Ba
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
48359, CBank-STR:10096
- Compound ID: 24210
Structure type: oligomer
Trivial name: soyasaponin IV, saponin Bc', soyasaponin Bc'
Compound class: saponin glycoside, glycoside, triterpenoid glycoside
Reference(s) to other database(s): CCSD:
48363, CBank-STR:3230
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