Sixteen triterpenoid saponins, astrasieversianins I–XVI, have been isolated from the methanol extract of the roots of Astragalus sieversianus. By heterogeneous acidic hydrolysis, all glycosides produced only one common aglycone which was identified as the known natural product astramembrangenin or cycloastragenol. On the basis of spectral analysis and chemical reactions, the structures of two new triterpenoid glycosides, astrasieversianin IX and XI, were assigned as the 3-0-[α-l-rhamnopyranosyl(1→2)]-(3′-O-acetyl)-β-d-xylopyranosyl-6-O-β-d-xylopyranoside and the 3-O-[α-l-rhamnopyranosyl(1→2)]-(4′-O-acetyl)-β-d-xylopyranosyl-6-β-d-xylopyranoside of cycloastragenol. Astrasieversianin XV was identified as the 20,24-epimer (20R,24S) of cyclosieversiside G (20S,24R).

Leguminosae, triterpenoid saponins, Astragalus sieversianus, cycloartane triterpene, astrasieversianin, astrasieversiagenin

• Compound ID: 27165
  

  b-D-Xylp-(1-6)-+ | a-L-Rhap-(1-2)-b-D-Xylp3Ac-(1-3)-Subst Subst = astramembrangenin = SMILES CC1(C){3}[C@@H](O)CC[C@]2(C3)C43CC[C@]5(C)[C@@H]([C@](C)(O6)CC[C@H]6{25}C(C)(O)C){16}[C@@H](O)C[C@](C)5[C@]4([H])C{6}[C@H](O)[C@@]12[H]

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  Structure type: oligomer ; 965 [M+Na]+
  Trivial name: astrasieversianin IX
  Compound class: glycoside
  Reference(s) to other database(s): CCSD:49748, CBank-STR:6666
  
   
  
  Astragalus sieversianus
  CSDB ID 145493 (all data & tools)
• Compound ID: 27166
  

  b-D-Xylp-(1-6)-+ | a-L-Rhap-(1-2)-b-D-Xylp4Ac-(1-3)-Subst Subst = astramembrangenin = SMILES CC1(C){3}[C@@H](O)CC[C@]2(C3)C43CC[C@]5(C)[C@@H]([C@](C)(O6)CC[C@H]6{25}C(C)(O)C){16}[C@@H](O)C[C@](C)5[C@]4([H])C{6}[C@H](O)[C@@]12[H]

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  Structure type: oligomer ; 943 [M+H]+
  Trivial name: astrasieversianin XI
  Compound class: glycoside
  Reference(s) to other database(s): CCSD:49749, CBank-STR:6667
  
   
  
  Astragalus sieversianus
  CSDB ID 145494 (all data & tools)
• Compound ID: 27167
  

  b-D-Xylp-(1-6)-+ | a-L-Rhap-(1-2)-b-D-Xylp-(1-3)-Subst Subst = astramembrangenin = SMILES CC1(C){3}[C@@H](O)CC[C@]2(C3)C43CC[C@]5(C)[C@@H]([C@](C)(O6)CC[C@H]6{25}C(C)(O)C){16}[C@@H](O)C[C@](C)5[C@]4([H])C{6}[C@H](O)[C@@]12[H]

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  Structure type: oligomer ; 901 [M+H]+
  Trivial name: astrasieversianin XV
  Compound class: glycoside
  Reference(s) to other database(s): CCSD:49750, CBank-STR:6665
  
   
  
  Astragalus sieversianus
  CSDB ID 145495 (all data & tools)