Found 1 structure.
Displayed structure 1
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1. Compound ID: 11090
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b-D-Galp-(1-8)-a-Kdop-(2-4)-+
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a-D-Manp-(1-6)-+ |
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-5)-a-Kdop-(2--/lipid A/ |
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Structure type: oligomer
Aglycon: lipid A
Compound class: LPS
Contained glycoepitopes: IEDB_130650,IEDB_130659,IEDB_130701,IEDB_136044,IEDB_136104,IEDB_137472,IEDB_140116,IEDB_141793,IEDB_141794,IEDB_141830,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_153220,IEDB_164174,IEDB_190606,IEDB_236390,IEDB_241100,IEDB_983930,SB_136,SB_165,SB_166,SB_187,SB_195,SB_196,SB_197,SB_198,SB_44,SB_67,SB_7,SB_72,SB_73,SB_88
The structure is contained in the following publication(s):
- Article ID: 4480
Bernardi A, Jiménez-Barbero J, Casnati A, De Castro C, Darbre T, Fieschi F, Finne J, Funken H, Jaeger KE, Lahmann M, Lindhorst TK, Marradi M, Messner P, Molinaro A, Murphy PV, Nativi C, Oscarson S, Penades S, Peri F, Pieters RJ, Renaudet O, Reymond JL, Richichi B, Rojo J, Sansone F, Schäffer C, Turnbull WB, Velasco-Torrijos T, Vidal S, Vincent S, Wennekes T, Zuilhof H, Imberty A "Multivalent glycoconjugates as anti-pathogenic agents" -
Chemical Society Reviews 42(11) (2013) 4709-4727
Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
glycoconjugates, vaccine, immune response, adhesion, protein-glycan recognition
NCBI PubMed ID: 23254759Publication DOI: 10.1039/c2cs35408jJournal NLM ID: 0335405Publisher: London: Chemical Society
Correspondence: Imberty@cermav.cnrs.fr
Institutions: Universita di Milano, Dipartimento di Chimica Organica e Industriale and Centro di Eccellenza CISI, via Venezian 21, 20133 Milano, Italy
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