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1. (Article ID: 11103)
 
Qiu SX, Lin LZ, Cordell GA, Ramesh M, Kumar BR, Radhakrishna M, Mohan GK, Reddy BM, Rao YN, Srinivas B, Thomas NS, Rao AV
Acylated C-21 steroidal bisdesmosidic glycosides from Caraluma umbellata
Phytochemistry 46(2) (1997) 333-340
 

From the whole plant of Caraluma umbellata, three new C-21 steroidal glycosides, named as carumbellosides III-V, were isolated and their structures elucidated by extensive spectroscopic experiments, devoid of any derivatisation, as caralumagenin 3-O-β-D-glucopyranosyl(1→4)-β-D-digitalopyranoside-20-O-β-D-glucopyranoside, caralumagenin 3-O-β-D-glycopyranosyl(1→4)-β-D-digitalopyranoside-20-O-(2-O-benzoyl)-β-D-glucopyranoside side and caralumagenin 3-O-[6-O-benzoyl-β-D-glucopyranosyl(1→4)]-β-D-digitalopyranoside-20-O-(2-O-benzoyl)-β-D-glucopyranoside. The determination of the absolute configuration of the aglycone as (20R), the conformations of the sugars and the unambiguous assignments of their NMR spectroscopic signals were achieved by a combination of 2D-NMR techniques. The isolates were devoid of significant cytotoxity in the UIC human cancer cell panel.

structure elucidation, Asclepiadaceae, NMR assignments, two-dimensional NMR techniques, Caraluma unbellata, C-21 steroidal glycosides, Bisdemosidic glycosides, Caralumagenin, Carumbelloside III, Carumbelloside IV;, Carumbelloside V

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2. (Article ID: 11762)
 
Ramesh M, Rao YN, Kumar MR, Venkata A, Rao NA, Prabhakar MC, Reddy BM
Antinociceptive and anti-inflammatory activity of carumbelloside I isolated from Caralluma umbellata
Journal of Ethnopharmacology 68(1-3) (1999) 349-352
 

The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole plant allowed the isolation of a novel pregnane glycoside named carumbelloside I (3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one). Carumbelloside I was evaluated for both antinociceptive activity and anti-inflammatory activity. The antinociceptive activity was evaluated in mice using the writhing test method, while the anti-inflammatory activity was evaluated in rats using the paw edema test with carrageenin. Carumbelloside I has significant antinociceptive action. It has no anti-inflammatory activity.

Asclepiadaceae, pregnane glycoside, Caralluma umbellata, antinociceptive activityAnti-inflammatory activity, carumbelloside-I, 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β, 14β-dihydroxypregn-5-en-20-one

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