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1. (Article ID: 11116)
Shao Y, Ho CT, Chin CK
Asterlingulatosides C and D, cytotoxic triterpenoid saponins from Aster lingulatus
Journal of Natural Products 60(7) (1997)
743-746
A further investigation of Aster lingulatus has led to the isolation of two additional novel triterpene saponins, asterlingulatoside C [3-O-β-D-glucopyranosyl-3β,16α-dihydroxyolean-12-en-28-oic acid 28-O-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside] (1) and asterlingulatoside D [3-O-β-D-glucopyranosyl-3β,16α-dihydroxyolean-12-en-28-oic acid 28-O-β-D-xylopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside] (2). Elucidation of the structures of 1 and 2 was mainly based on FABMS and 1D and 2D homonuclear and heteronuclear NMR techniques. Compounds 1 and 2 showed good inhibitory activity against DNA synthesis in human leukemia HL-60 cells with IC50 values of 8.8 and 6.1 microM, respectively.
NCBI PubMed ID: 9249983Publication DOI: 10.1021/np970080tJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Institutions: Department of Plant Science, Cook College, Rutgers, State University of New Jersey, New Brunswich 08903, USA
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, IR, FAB-MS, TLC, acid hydrolysis, chemical methods, biological assays, NMR-1D, alkaline hydrolysis
The publication contains the following compound(s):
- Compound ID: 27749
|
b-D-Glcp-(1-3)-+
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b-D-Xylp-(1-4)-a-L-Rhap-(1-2)-a-L-Arap-(1-28)-Echinocystic |
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Structure type: oligomer
; 1043 [M-H]-
C52H84O21
Trivial name: asterlingulatoside C
Compound class: saponin glycoside
- Compound ID: 27750
|
b-D-Glcp-(1-3)-+
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b-D-Xylp-(1-3)-b-D-Xylp-(1-4)-a-L-Rhap-(1-2)-a-L-Arap-(1-28)-Echinocystic |
Show graphically |
Structure type: oligomer
; 1175 [M-H]-
C57H92O25
Trivial name: asterlingulatoside D
Compound class: saponin glycoside
- Compound ID: 27751
Structure type: oligomer
Trivial name: asterlingulatoside A
Compound class: saponin glycoside
- Compound ID: 27752
Structure type: oligomer
C47H76O17
Trivial name: asterlingulatoside B
Compound class: saponin glycoside
- Compound ID: 27753
Structure type: oligomer
C47H76O17
Trivial name: prosapogenin methyl ester
Compound class: saponin glycoside
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2. (Article ID: 11199)
Shao Y, Ho CT, Chin CK, Rosen RT, Hu B, Qin GW
Triterpenoid saponins from Aster lingulatus
Phytochemistry 44(2) (1997)
337-340
Two new triterpenoid saponins named asterlingulatosides A and B were isolated from the whole plants of Aster lingulatus. Their structures were determined by spectroscopic data and chemical transformations to be 3-O-β-D-glucopyranosyl-3β,16α-dihydroxyolean-12-en-28-oic acid-28-O-α-L-O-arabinopyranoside and 3-O-β-D-glucopyranosyl-3β,16α-dihydroxyolean-12-en-28-oic acid-28-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside. They showed inhibitory activity on DNA synthesis in human leukaemia HL-60 cells.
compositae, triterpenoid saponins, Aster lingulatus, asterlingulatosides A and B, DNA synthesis inhibition
NCBI PubMed ID: 9004546Publication DOI: 10.1016/S0031-9422(96)00551-1Journal NLM ID: 0151434Publisher: Elsevier
Institutions: Department of Plant Science, Cook College, Rutgers, State University of New Jersey, New Brunswick 08903, USA
Methods: 13C NMR, 1H NMR, IR, sugar analysis, TLC, ESI-MS, acid hydrolysis, chemical methods, alkaline hydrolysis, extraction
The publication contains the following compound(s):
- Compound ID: 28205
Structure type: monomer
Compound class: saponin glycoside
- Compound ID: 28203
Structure type: oligomer
; 765 [M-H]-
C41H66O13
Trivial name: asterlingulatosides A
Compound class: saponin glycoside
- Compound ID: 28204
Structure type: oligomer
; 911 [M-H]-
C47H76O17
Trivial name: asterlingulatosides B
Compound class: saponin glycoside
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