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1. (Article ID: 1125)
 
Ragousis V, Leondiadis L, Livaniou E, Evangelatos GP
A simple approach to the synthesis of muramic acid and isomuramic acid: 1H and 13C NMR characterisation
Carbohydrate Research 297(3) (1997) 289-295
 

A simple and efficient synthesis of 2-amino-3-O-[(R)-1-carboxyethyl]-2-deoxy-D-glucose (muramic acid, 6) and its stereoisomer 2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose (isomuramic acid, 7) from methyl 2-acetamido-4,6-O-benzylidene-2-deoxy-a-D-glucopyranoside (1) is described. Condensation of the O-3 oxyanion of 1 with an excess of methyl (R,S)-2-bromopropionate, followed by alkaline hydrolysis of the crude product and subsequent acidification, afforded crystalline methyl 2-acetamido-4,6-O-benzylidene-3-O-[(R,S)-1-carboxyethyl]-2-deoxy-a-D-glucopyranoside (2), in 72% yeld, as a mixture of diastereomers. Esterification of 2 with an excess of diazomethane afforded quantitatively the corresponding mixture of epimeric esters, which were very easily separated by column chromatography on silica gel, giving pure (R) and (S) epimeric esters. Removal of the benzylidene and acetyl groups by acid hydrolysis gave, respectively, muramic acid (6), in 95% yield and isomuramic acid (7), in 93% yield. 1H and 13C NMR data are given.

NMR, synthesis, acid, 13C NMR, characterisation, 1H NMR, approach, isomuramic acid, muramic acid, 2-acetamido-2-deoxyglucosides

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2. (Article ID: 2327)
 
Schweda E
Structural studies of some bacterial lipopolysaccharides and NMR and conformational studies of some mono- and disaccharide derivatives
Chemical Communications 3 (1987) 1-42
 
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3. (Article ID: 2328)
 
Minami Y, Yazawa K, Tamura Z, Tanaka T, Yamamoto T
Selectivity of utilization of galactosyl-oligosaccharides by bifidobacteria
Chemical and Pharmaceutical Bulletin 31 (1983) 1688-1691
 
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