Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Klebsiella [ICD11:
XN620 
]
The structure was elucidated in this paperPublication DOI: 10.1016/S0008-6215(00)87023-8Journal NLM ID: 0043535Publisher: Elsevier
Institutions: Max Planck-Instiut fu¨r Immunbiologie, and Institut fu¨r Makromolekulare Chemie der Universita´t, Freiburg Germany
Using periodate oxidation, methylation analysis, the characterization of oligosaccharides obtained by partial acid hydrolysis, p.m.r. spectroscopy, and analytical ultracentrifugation, the structure of the (mildly alkali-treated) Klebsiella serotype 11 capsular polysaccharide has been elucidated. The tetrasaccharide repeating-unit comprises the sequence -3)-β-D-Glcp-(1-3)-β-D-GlcUAp-(1-3)-α-D-Galp-(1→ with a 4,6-O-(1-carboxyethylidene)-α-D-galactosyl residue linked to O-4 of the glucuronic acid residue. The structural basis for some serological cross-reactions of the Klebsiella K11 antigen is discussed, and it is shown that rabbit antisera against the Klebsiella K11 test-strain predominantly contain K agglutinins specific for branch-terminal 4,6-O-(1-carboxyethylidene)-D-galactose.
Structure type: polymer chemical repeating unit
Compound class: CPS
Contained glycoepitopes: IEDB_115136,IEDB_136906,IEDB_137472,IEDB_140630,IEDB_141794,IEDB_142488,IEDB_146664,IEDB_151528,IEDB_151770,IEDB_190606,IEDB_423153,IEDB_983931,SB_192,SB_7
Methods: 1H NMR, methylation, periodate oxidation, gel filtration, IR, partial acid hydrolysis, sugar analysis, Smith degradation, paper chromatography, immunodiffusion assays, paper electrophoresis, serological cross-reactions
Related record ID(s): 130203, 134161
NCBI Taxonomy refs (TaxIDs): 576
Show glycosyltransferases
SMILES errors: -3)bDGlcp(1-3)[xRPyr(2-6:2-4)aDGalp(1-4)]bDGlcpA(1-3)aDGalp(1-:
SMILES error: unpredicted error with SMILES generation. 'bDGlcpA' is not in list
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